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Khanal, Rajendra; Heinen, Natalie; Bogomolova, Alexandra; Meister, Toni L; Herrmann, Simon T; Westhoven, Saskia; Nocke, Maximilian K; Todt, Daniel; Jockenhövel, Freya; Klein, Isabel M; Hartmann, Laura; Vondran, Florian W R; Steinmann, Eike; Zimmer, Gert; Ott, Michael; Brown, Richard J P; Sharma, Amar Deep; Pfaender, Stephanie (2024). MicroRNAs modulate SARS-CoV-2 infection of primary human hepatocytes by regulating the entry factors ACE2 and TMPRSS2. (In Press). Liver international Wiley 10.1111/liv.16079
Avanthay, Robin; Garcia Nicolas, Obdulio; Ruggli, Nicolas; Grau Roma, Llorenç; Párraga-Ros, Ester; Summerfield, Artur; Zimmer, Gert (2024). Evaluation of a novel intramuscular prime/intranasal boost vaccination strategy against influenza in the pig model. PLoS pathogens, 20(8) Public Library of Science 10.1371/journal.ppat.1012393
Graaf-Rau, Annika; Schmies, Kathrin; Breithaupt, Angele; Ciminski, Kevin; Zimmer, Gert; Summerfield, Artur; Sehl-Ewert, Julia; Lillie-Jaschniski, Kathrin; Helmer, Carina; Bielenberg, Wiebke; Grosse Beilage, Elisabeth; Schwemmle, Martin; Beer, Martin; Harder, Timm (2024). Reassortment incompetent live attenuated and replicon influenza vaccines provide improved protection against influenza in piglets. npj vaccines, 9(127) Nature Publishing Group 10.1038/s41541-024-00916-x
Leborgne, Nathan GF; Devisme, Christelle; Kozarac, Nedim; Berenguer Veiga, Inês; Ebert, Nadine; Godel, Aurélie; Grau Roma, Llorenç; Scherer, Melanie; Plattet, Philippe; Thiel, Volker; Zimmer, Gert; Taddeo, Adriano; Benarafa, Charaf (2024). Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation. JCI insight, 9(7) JCI Insight 10.1172/jci.insight.174133
Thompson, Danielle; Cismaru, Christiana Victoria; Rougier, Jean-Sébastien; Schwemmle, Martin; Zimmer, Gert (2023). The M2 proteins of bat influenza A viruses reveal atypical features compared to conventional M2 proteins. Journal of virology, 97(8), e0038823. American Society for Microbiology 10.1128/jvi.00388-23
Avanthay, Robin; Garcia-Nicolas, Obdulio; Zimmer, Gert; Summerfield, Artur (2023). NS1 and PA-X of H1N1/09 influenza virus act in a concerted manner to manipulate the innate immune response of porcine respiratory epithelial cells. Frontiers in cellular and infection microbiology, 13(1222805), p. 1222805. Frontiers 10.3389/fcimb.2023.1222805
García-Nicolás, O; Godel, A; Zimmer, G; Summerfield, A (2023). Macrophage phagocytosis of SARS-CoV-2-infected cells mediates potent plasmacytoid dendritic cell activation. Cellular & molecular immunology, 20(7), pp. 835-849. Nature Publ. Group 10.1038/s41423-023-01039-4
Brigger, Daniel; Guntern, Pascal; Jonsdottir, Hulda R; Pennington, Luke F; Weber, Benjamin; Taddeo, Adriano; Zimmer, Gert; Leborgne, Nathan G F; Benarafa, Charaf; Jardetzky, Theodore S; Eggel, Alexander (2023). Sex-specific differences in immune response to SARS-CoV-2 vaccination vanish with age. Allergy, 78(6), pp. 1683-1686. Wiley 10.1111/all.15652
Aicher, Sophie-Marie; Streicher, Felix; Chazal, Maxime; Planas, Delphine; Luo, Dongsheng; Buchrieser, Julian; Nemcova, Monika; Seidlova, Veronika; Zukal, Jan; Serra-Cobo, Jordi; Pontier, Dominique; Pain, Bertrand; Zimmer, Gert; Schwartz, Olivier; Roingeard, Philippe; Pikula, Jiri; Dacheux, Laurent; Jouvenet, Nolwenn (2022). Species-Specific Molecular Barriers to SARS-CoV-2 Replication in Bat Cells. Journal of virology, 96(14), e0060822. American Society for Microbiology 10.1128/jvi.00608-22
Taddeo, Adriano; Berenguer Veiga, Inês; Devisme, Christelle; Boss, Renate; Plattet, Philippe; Weigang, Sebastian; Kochs, Georg; Thiel, Volker; Benarafa, Charaf; Zimmer, Gert (2022). Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior immune response to SARS-CoV-2. NPJ vaccines, 7(1), p. 82. Springer Nature 10.1038/s41541-022-00508-7
Callegari, Ilaria; Schneider, Mika; Berloffa, Giuliano; Mühlethaler, Tobias; Holdermann, Sebastian; Galli, Edoardo; Roloff, Tim; Boss, Renate; Infanti, Laura; Khanna, Nina; Egli, Adrian; Buser, Andreas; Zimmer, Gert; Derfuss, Tobias; Sanderson, Nicholas S R (2022). Potent neutralization by monoclonal human IgM against SARS-CoV-2 is impaired by class switch. EMBO reports, 23(7), e53956. EMBO press 10.15252/embr.202153956
Mac Kain, Alice; Maarifi, Ghizlane; Aicher, Sophie-Marie; Arhel, Nathalie; Baidaliuk, Artem; Munier, Sandie; Donati, Flora; Vallet, Thomas; Tran, Quang Dinh; Hardy, Alexandra; Chazal, Maxime; Porrot, Françoise; OhAinle, Molly; Carlson-Stevermer, Jared; Oki, Jennifer; Holden, Kevin; Zimmer, Gert; Simon-Lorière, Etienne; Bruel, Timothée; Schwartz, Olivier; ... (2022). Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen. Nature Communications, 13(1), p. 2442. Springer Nature 10.1038/s41467-022-30134-9
Walter, Justin D; Scherer, Melanie; Hutter, Cedric A J; Garaeva, Alisa A; Zimmermann, Iwan; Wyss, Marianne; Rheinberger, Jan; Ruedin, Yelena; Earp, Jennifer C; Egloff, Pascal; Sorgenfrei, Michèle; Hürlimann, Lea M; Gonda, Imre; Meier, Gianmarco; Remm, Sille; Thavarasah, Sujani; van Geest, Geert; Bruggmann, Rémy; Zimmer, Gert; Slotboom, Dirk J; ... (2022). Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance. EMBO reports, 23(4), e54199. EMBO press 10.15252/embr.202154199
Heinen, Natalie; Marheinecke, Corinna Sophie; Bessen, Clara; Blazquez-Navarro, Arturo; Roch, Toralf; Stervbo, Ulrik; Anft, Moritz; Plaza-Sirvent, Carlos; Busse, Sandra; Klöhn, Mara; Schrader, Jil; Vidal Blanco, Elena; Urlaub, Doris; Watzl, Carsten; Hoffmann, Markus; Pöhlmann, Stefan; Tenbusch, Matthias; Steinmann, Eike; Todt, Daniel; Hagenbeck, Carsten; ... (2022). In-depth analysis of T cell immunity and antibody responses in heterologous prime-boost-boost vaccine regimens against SARS-CoV-2 and Omicron variant. Frontiers in immunology, 13, p. 1062210. Frontiers Research Foundation 10.3389/fimmu.2022.1062210
Kratzel, Annika; Kelly, Jenna N; V'kovski, Philip; Portmann, Jasmine; Brüggemann, Yannick; Todt, Daniel; Ebert, Nadine; Shrestha, Neeta; Plattet, Philippe; Staab-Weijnitz, Claudia A; von Brunn, Albrecht; Steinmann, Eike; Dijkman, Ronald; Zimmer, Gert; Pfaender, Stephanie; Thiel, Volker (2021). A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets. PLoS biology, 19(12), e3001490. Public Library of Science 10.1371/journal.pbio.3001490
Stervbo, Ulrik; Blazquez-Navarro, Arturo; Blanco, Elena Vidal; Safi, Lema; Meister, Toni L; Paniskaki, Krystallenia; Stockhausen, Mara; Marheinecke, Corinna; Zimmer, Gert; Wellenkötter, Jacqueline; Giglio, Tina; Arora, Prerna; Pöhlmann, Stefan; Hoffmann, Markus; Seibert, Felix S; Pfaender, Stephanie; Roch, Toralf; Westhoff, Timm H; Cinkilic, Okan and Babel, Nina (2021). Improved cellular and humoral immunity upon a second BNT162b2 and mRNA-1273 boost in prime-boost vaccination no/low responders with end-stage renal disease. Kidney international, 100(6), pp. 1335-1337. Elsevier 10.1016/j.kint.2021.09.015
Weigang, Sebastian; Fuchs, Jonas; Zimmer, Gert; Schnepf, Daniel; Kern, Lisa; Beer, Julius; Luxenburger, Hendrik; Ankerhold, Jakob; Falcone, Valeria; Kemming, Janine; Hofmann, Maike; Thimme, Robert; Neumann-Haefelin, Christoph; Ulferts, Svenja; Grosse, Robert; Hornuss, Daniel; Tanriver, Yakup; Rieg, Siegbert; Wagner, Dirk; Huzly, Daniela; ... (2021). Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants. Nature Communications, 12(1), p. 6405. Springer Nature 10.1038/s41467-021-26602-3
Cramer, Jonathan; Lakkaichi, Adem; Aliu, Butrint; Jakob, Roman P; Klein, Sebastian; Cattaneo, Ivan; Jiang, Xiaohua; Rabbani, Said; Schwardt, Oliver; Zimmer, Gert; Ciancaglini, Matias; Abreu Mota, Tiago; Maier, Timm; Ernst, Beat (2021). Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2. Journal of the American Chemical Society, 143(42), pp. 17465-17478. American Chemical Society 10.1021/jacs.1c06778
Sava, Mihaela; Sommer, Gregor; Daikeler, Thomas; Woischnig, Anne-Kathrin; Martinez, Aurelien E; Leuzinger, Karoline; Hirsch, Hans H.; Erlanger, Tobias; Wiencierz, Andrea; Bassetti, Stefano; Tamm, Michael; Tschudin-Sutter, Sarah; Stoeckle, Marcel; Pargger, Hans; Siegemund, Martin; Boss, Renate; Zimmer, Gert; Vu, Diem-Lan; Kaiser, Laurent; Dell-Kuster, Salome; ... (2021). Ninety-day outcome of patients with severe COVID-19 treated with tocilizumab - a single centre cohort study. Swiss medical weekly, 151(w20550), w20550. EMH Media 10.4414/smw.2021.20550
Garcia Nicolas, Obdulio; V'kovski, Philip; Zettl, Ferdinand; Zimmer, Gert; Thiel, Volker; Summerfield, Artur (2021). No Evidence for Human Monocyte-Derived Macrophage Infection and Antibody-Mediated Enhancement of SARS-CoV-2 Infection. Frontiers in cellular and infection microbiology, 11(644574), p. 644574. Frontiers 10.3389/fcimb.2021.644574
Zimmer, Gert (2021). Rhabdoviruses as Vaccine Vectors for Veterinary Pathogens. In: Vanniasinkam, Thiru; Tikoo, Suresh K.; Samal, Siba K. (eds.) Viral Vectors in Veterinary Vaccine Development: A Textbook (pp. 141-148). Springer 10.1007/978-3-030-51927-8_9
Moreno, Hector; Rastrojo, Alberto; Pryce, Rhys; Fedeli, Chiara; Zimmer, Gert; Bowden, Thomas A; Gerold, Gisa; Kunz, Stefan (2020). A novel circulating tamiami mammarenavirus shows potential for zoonotic spillover. PLoS neglected tropical diseases, 14(12), e0009004. Public Library of Science 10.1371/journal.pntd.0009004
Pfaender, Stephanie; Mar, Katrina B; Michailidis, Eleftherios; Kratzel, Annika; Boys, Ian N; V'kovski, Philip; Fan, Wenchun; Kelly, Jenna N.; Hirt, Dagny; Ebert, Nadine; Stalder, Hanspeter; Kleine-Weber, Hannah; Hoffmann, Markus; Heinrich Hoffmann, H; Saeed, Mohsan; Dijkman, Ronald; Steinmann, Eike; Wight-Carter, Mary; McDougal, Matthew B; Hanners, Natasha W; ... (2020). LY6E impairs coronavirus fusion and confers immune control of viral disease. Nature microbiology, 5(11), pp. 1330-1339. Springer Nature 10.1038/s41564-020-0769-y
Meyer, Benjamin; Torriani, Giulia; Yerly, Sabine; Mazza, Lena; Calame, Adrien; Arm-Vernez, Isabelle; Zimmer, Gert; Agoritsas, Thomas; Stirnemann, Jérôme; Spechbach, Hervé; Guessous, Idris; Stringhini, Silvia; Pugin, Jérôme; Roux-Lombard, Pascale; Fontao, Lionel; Siegrist, Claire-Anne; Eckerle, Isabella; Vuilleumier, Nicolas; Kaiser, Laurent (2020). Validation of a commercially available SARS-CoV-2 serological immunoassay. Clinical microbiology and infection, 26(10), pp. 1386-1394. Elsevier 10.1016/j.cmi.2020.06.024
Zettl, Ferdinand; Meister, Toni Luise; Vollmer, Tanja; Fischer, Bastian; Steinmann, Jörg; Krawczyk, Adalbert; V'kovski, Philip; Todt, Daniel; Steinmann, Eike; Pfaender, Stephanie; Zimmer, Gert (2020). Rapid Quantification of SARS-CoV-2-Neutralizing Antibodies Using Propagation-Defective Vesicular Stomatitis Virus Pseudotypes. Vaccines, 8(3) MDPI 10.3390/vaccines8030386
Torriani, Giulia; Mayor, Jennifer; Zimmer, Gert; Kunz, Stefan; Rothenberger, Sylvia; Engler, Olivier (2019). Macropinocytosis contributes to hantavirus entry into human airway epithelial cells. Virology, 531, pp. 57-68. Elsevier 10.1016/j.virol.2019.02.013
Torriani, Giulia; Trofimenko, Evgeniya; Mayor, Jennifer; Fedeli, Chiara; Moreno, Hector; Michel, Sébastien; Heulot, Mathieu; Chevalier, Nadja; Zimmer, Gert; Shrestha, Neeta; Plattet, Philippe; Engler, Olivier; Rothenberger, Sylvia; Widmann, Christian; Kunz, Stefan (2019). Identification of Clotrimazole Derivatives as Specific Inhibitors of Arenavirus Fusion. Journal of virology, 93(6) American Society for Microbiology 10.1128/JVI.01744-18
Karakus, Umut; Thamamongood, Thiprampai; Ciminski, Kevin; Ran, Wei; Günther, Sira C; Pohl, Marie O; Eletto, Davide; Jeney, Csaba; Hoffmann, Donata; Reiche, Sven; Schinköthe, Jan; Ulrich, Reiner; Wiener, Julius; Hayes, Michael G B; Chang, Max W; Hunziker, Annika; Yángüez, Emilio; Aydillo, Teresa; Krammer, Florian; Oderbolz, Josua; ... (2019). MHC class II proteins mediate cross-species entry of bat influenza viruses. Nature, 567(7746), pp. 109-112. Springer Nature 10.1038/s41586-019-0955-3
Krischuns, Tim; Günl, Franziska; Henschel, Lea; Binder, Marco; Willemsen, Joschka; Schloer, Sebastian; Rescher, Ursula; Gerlt, Vanessa; Zimmer, Gert; Nordhoff, Carolin; Ludwig, Stephan; Brunotte, Linda (2018). Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells. Frontiers in immunology, 9, p. 2229. Frontiers Research Foundation 10.3389/fimmu.2018.02229
Walz, Lisa; Kays, Sarah-Katharina; Zimmer, Gert; von Messling, Veronika (2018). Neuraminidase-Inhibiting Antibody Titers Correlate with Protection from Heterologous Influenza Virus Strains of the Same Neuraminidase Subtype. Journal of virology, 92(17) American Society for Microbiology 10.1128/JVI.01006-18
Locher, Samira; Schweneker, Marc; Hausmann, Jürgen; Zimmer, Gert (2018). Immunogenicity of propagation-restricted vesicular stomatitis virus encoding Ebola virus glycoprotein in guinea pigs. Journal of general virology, 99(7), pp. 866-879. Society for General Microbiology 10.1099/jgv.0.001085
Galan-Navarro, Clara; Rincon-Restrepo, Marcela; Zimmer, Gert; Ollmann Saphire, Erica; Hubbell, Jeffrey A; Hirosue, Sachiko; Swartz, Melody A; Kunz, Stefan (2017). Oxidation-sensitive polymersomes as vaccine nanocarriers enhance humoral responses against Lassa virus envelope glycoprotein. Virology, 512, pp. 161-171. Academic Press 10.1016/j.virol.2017.09.013
Ricklin, Meret; Python, Sylvie; Vielle, Nathalie Jane; Brechbühl, Daniel; Zumkehr, Béatrice; Posthaus, Horst; Zimmer, Gert; Ruggli, Nicolas; Summerfield, Artur (2017). Virus replicon particle vaccines expressing nucleoprotein of influenza A virus mediate enhanced inflammatory responses in pigs. Scientific Reports, 7(1), p. 16379. Nature Publishing Group 10.1038/s41598-017-16419-w
Ciminski, Kevin; Thamamongood, Thiprampai; Zimmer, Gert; Schwemmle, Martin (2017). Novel insights into bat influenza A viruses. Journal of general virology, 98(10), pp. 2393-2400. Society for General Microbiology 10.1099/jgv.0.000927
Fuchs, Jonas; Hölzer, Martin; Schilling, Mirjam; Patzina, Corinna; Schoen, Andreas; Hoenen, Thomas; Zimmer, Gert; Marz, Manja; Weber, Friedemann; Müller, Marcel A; Kochs, Georg (2017). Evolution and Antiviral Specificities of Interferon-Induced Mx Proteins of Bats against Ebola, Influenza, and Other RNA Viruses. Journal of virology, 91(15) American Society for Microbiology 10.1128/JVI.00361-17
Schweneker, Marc; Laimbacher, Andrea S; Zimmer, Gert; Wagner, Susanne; Schraner, Elisabeth M; Wolferstätter, Michael; Klingenberg, Marieken; Dirmeier, Ulrike; Steigerwald, Robin; Lauterbach, Henning; Hochrein, Hubertus; Chaplin, Paul; Suter, Mark; Hausmann, Jürgen (2017). Recombinant Modified Vaccinia Virus Ankara Generating Ebola Virus-Like Particles. Journal of virology, 91(11) American Society for Microbiology 10.1128/JVI.00343-17
Moreira, Étori Aguiar; Locher, Samira; Kolesnikova, Larissa; Bolte, Hardin; Aydillo, Teresa; García-Sastre, Adolfo; Schwemmle, Martin; Zimmer, Gert (2016). Synthetically derived bat influenza A-like viruses reveal a cell type- but not species-specific tropism. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 113(45), pp. 12797-12802. National Academy of Sciences NAS 10.1073/pnas.1608821113
Fallet, Benedict; Narr, Kerstin; Ertuna, Yusuf I; Remy, Melissa; Sommerstein, R.; Cornille, Karen; Kreutzfeldt, Mario; Page, Nicolas; Zimmer, Gert; Geier, Florian; Straub, Tobias; Pircher, Hanspeter; Larimore, Kevin; Greenberg, Philip D; Merkler, Doron; Pinschewer, Daniel D (2016). Interferon-driven deletion of antiviral B cells at the onset of chronic infection. Science immunology, 1(4) American Association for the Advancement of Science 10.1126/sciimmunol.aah6817
Moreira, Étori Aguiar; Weber, Anna; Bolte, Hardin; Kolesnikova, Larissa; Giese, Sebastian; Lakdawala, Seema; Beer, Martin; Zimmer, Gert; García-Sastre, Adolfo; Schwemmle, Martin; Juozapaitis, Mindaugas (2016). A conserved influenza A virus nucleoprotein code controls specific viral genome packaging. Nature communications, 7(12861), p. 12861. Nature Publishing Group 10.1038/ncomms12861
Moeschler, Sarah; Locher, Samira; Conzelmann, Karl-Klaus; Krämer, Beate; Zimmer, Gert (2016). Quantification of Lyssavirus-Neutralizing Antibodies Using Vesicular Stomatitis Virus Pseudotype Particles. Viruses, 8(9) MDPI 10.3390/v8090254
Eck, Melanie; Durán, Margarita García; Ricklin, Meret; Locher, Samira; Sarraseca, Javier; Rodríguez, María José; McCullough, Kenneth; Summerfield, Artur; Zimmer, Gert; Ruggli, Nicolas (2016). Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs. Veterinary research, 47(33), p. 33. BioMed Central 10.1186/s13567-016-0318-0
Ricklin, Meret; Vielle, Nathalie Jane; Python, Sylvie; Brechbühl, Daniel; Zumkehr, Beatrice; Posthaus, Horst; Zimmer, Gert; Summerfield, Artur (2016). Partial Protection against Porcine Influenza A Virus by a Hemagglutinin-Expressing Virus Replicon Particle Vaccine in the Absence of Neutralizing Antibodies. Frontiers in immunology, 7(253), p. 253. Frontiers Research Foundation 10.3389/fimmu.2016.00253
Bolz, Miriam; Kerber, Sarah; Zimmer, Gert; Pluschke, Gerd (2015). Use of Recombinant Virus Replicon Particles for Vaccination against Mycobacterium ulcerans Disease. PLoS neglected tropical diseases, 9(8), e0004011. Public Library of Science 10.1371/journal.pntd.0004011
Halbherr, Stefan J; Ludersdorfer, Thomas H; Ricklin, Meret; Locher, Samira; Berger Rentsch, Marianne; Summerfield, Artur; Zimmer, Gert (2015). Biological and protective properties of immune sera directed to the influenza virus neuraminidase. Journal of virology, 89(3), pp. 1550-1563. American Society for Microbiology 10.1128/JVI.02949-14
Zimmer, Gert; Locher, Samira; Berger Rentsch, Marianne; Halbherr, Stefan J (2014). Pseudotyping of vesicular stomatitis virus with the envelope glycoproteins of highly pathogenic avian influenza viruses. Journal of general virology, 95(Pt 8), pp. 1634-1639. Society for General Microbiology 10.1099/vir.0.065201-0
Bolz, Miriam; Ruggli, Nicolas; Ruf, Marie-Thérèse; Ricklin, Meret E; Zimmer, Gert; Pluschke, Gerd (2014). Experimental infection of the pig with Mycobacterium ulcerans: a novel model for studying the pathogenesis of Buruli ulcer disease. PLoS neglected tropical diseases, 8(7), e2968. Public Library of Science 10.1371/journal.pntd.0002968
Juozapaitis, Mindaugas; Aguiar Moreira, Étori; Mena, Ignacio; Giese, Sebastian; Riegger, David; Pohlmann, Anne; Höper, Dirk; Zimmer, Gert; Beer, Martin; García-Sastre, Adolfo; Schwemmle, Martin (2014). An infectious bat-derived chimeric influenza virus harbouring the entry machinery of an influenza A virus. Nature communications, 5, p. 4448. Nature Publishing Group 10.1038/ncomms5448
Kochinger, Stefanie (2014). Development of a novel marker vaccine platform for protection against Bluetongue Virus (BTV). (Dissertation, University of Bern, Graduate School for Cellular and Biomedical Sciences)
Kochinger, Stefanie; Renevey, Nathalie; Hofmann, Martin A; Zimmer, Gert (2014). Vesicular stomatitis virus replicon expressing the VP2 outer capsid protein of bluetongue virus serotype 8 induces complete protection of sheep against challenge infection. Veterinary research, 45(1), p. 64. BioMed Central 10.1186/1297-9716-45-64
