Factors associated with anitmicrobial resistant gonorrheoea infections in men who have sex with men in Switzerland: case control study

Abraha, Million; Bertisch, Barbara; Hauser, Christoph; Klutschke, Michael; Egli-Gany, Dianne; Smid, Joost; Unemo, Magnus; Endimiani, Andrea; Donà, Valentina; Furrer, Hansjakob; Low, Nicola; Kasraian Fard, Sara (23 November 2017). Factors associated with anitmicrobial resistant gonorrheoea infections in men who have sex with men in Switzerland: case control study. In: Swiss Public Health Conference 2017. Congress Center Basel. 22 - 23 Nov 2017.

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Introduction Antibiotic resistant Neisseria gonorrhoeae (NG) is a global public health challenge; resistance has emerged to all antibiotics used for empirical treatment. In Switzerland, gonorrhoea reports increased from 404 in 2000 to 1895 in 2015, with about 40% in men who have sex with men (MSM). To our knowledge, no studies have examined factors associated with antibiotic resistant NG in Switzerland. Methods We enrolled MSM at clinics in Zürich and Bern from May 2015 to June 2016 presenting with symptoms suggestive of NG, partners of known cases or had a positive NG screening test. MSM completed an online questionnaire on social and behavioural factors and physicians completed a case report form. Specimens from pharynx, rectum and urethra were tested with a molecular test and culture. For culture positive specimens, the minimum inhibitory concentration (MIC) for different antibiotics was determined, using EUCAST 2017 resistance breakpoints for ciprofloxacin, ceftriaxone, cefixime and spectinomycin, and ≥2mg/L for azithromycin (as in a European study). We also examined reduced susceptibility to ceftriaxone (cutoff ≥0.016 mg/L). Cases were MSM with NG and MIC above the breakpoint, controls were MSM with NG and MIC less than or equal to the breakpoint. We used logistic regression to estimate odds ratios (OR) with 95% confidence intervals (CI). Results In total, 164/230 (71%) MSM were positive for NG; culture was positive in 118/164. We compared 45 (39%) cases with ciprofloxacin resistance with 73 controls. Cases were more likely than controls to have concurrent sexual partners (OR 2.2, 95%Cl 0.876.0, p=0.13), to have received oral sex (OR 5.3, 0.644.2, p=0.08), to have had sex abroad in the last three months (OR 2.3, 1.04.9, p=0.08) and for the most recent partner to be casual (OR 2.6, 0.88.5 p=0.08). One NG isolate was azithromycin resistant. No isolates were resistant to spectinomycin, cefixime or ceftriaxone; 21 (18%) had reduced susceptibility to ceftriaxone, but we found no associations with clinical or behavioural factors. Conclusions This study had a limited sample size but is the first in Switzerland to link behavioural factors with antibiotic resistant NG. Ciprofloxacin resistance was common in MSM and there is evidence of reduced susceptibility to ceftriaxone. Interventions for MSM to promote safer sex, especially whilst abroad, and enhanced surveillance of antimicrobial susceptibility could help to identify and control emerging resistance in NG.

Item Type:

Conference or Workshop Item (Poster)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research

UniBE Contributor:

Abraha, Million; Egli, Dianne; Smid, Joost Hubert; Endimiani, Andrea; Donà, Valentina; Furrer, Hansjakob; Low, Nicola and Kasraian Fard, Sara

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

07 Jun 2018 16:34

Last Modified:

11 Jun 2018 09:43

BORIS DOI:

10.7892/boris.116926

URI:

https://boris.unibe.ch/id/eprint/116926

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