Künzli, Andrea Brigitte; Marschall, Jonas; Schefold, Joerg C.; Schafer, Margaret; Engler, Oliver B; Ackermann-Gäumann, Rahel; Reineke, David C; Suter, Franziska Marta; Staehelin, Cornelia (2018). Hantavirus Cardiopulmonary Syndrome Due to Imported Andes Hantavirus Infection in Switzerland: A Multidisciplinary Challenge, Two Cases and a Literature Review. Clinical infectious diseases, 67(11), pp. 1788-1795. Oxford Univ. Press 10.1093/cid/ciy443
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2018 - Kuenzli - IDSA - PMID 30084955.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (376kB) | Preview |
Two travellers returning from South America were diagnosed with Andes hantavirus infection, the only member of the Hantaviridae family known to be transmitted from person to person. We describe the clinical course and therapeutic and infection control measures. While both patients showed high viral load (VL) and shedding over several months, 1 patient recovered within 1 week from severe respiratory illness that required noninvasive ventilation, whereas the second patient developed severe hantavirus cardiopulmonary syndrome that required extracorporeal membrane oxygenation for 27 days. The clinical course in the latter patient was complicated by severe disseminated intravascular coagulopathy with diffuse hemorrhage that necessitated mass transfusions, as well as by multiple organ failure, including the need for renal replacement therapy. Results of VL in blood, respiratory secretions, and semen for the first 9 months of follow-up are reported. To our knowledge, these are the first cases of Andes hantavirus infection detected in Europe.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases 04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care |
UniBE Contributor: |
Künzli, Andrea Brigitte, Marschall, Jonas, Schefold, Jörg Christian, Schafer, Margaret, Suter, Franziska Marta, Staehelin, Cornelia |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
1058-4838 |
Publisher: |
Oxford Univ. Press |
Language: |
English |
Submitter: |
Mirella Aeberhard |
Date Deposited: |
10 Aug 2018 08:12 |
Last Modified: |
02 Mar 2023 23:31 |
Publisher DOI: |
10.1093/cid/ciy443 |
PubMed ID: |
30084955 |
BORIS DOI: |
10.7892/boris.119169 |
URI: |
https://boris.unibe.ch/id/eprint/119169 |
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