Current status and trends in the diagnostics of AML and MDS.

Shumilov, Evgenii; Flach, Johanna; Kohlmann, Alexander; Banz Wälti, Yara; Bonadies, Nicolas; Fiedler, Martin; Pabst, Thomas; Bacher, Ulrike (2018). Current status and trends in the diagnostics of AML and MDS. Blood reviews, 32(6), pp. 508-519. Elsevier 10.1016/j.blre.2018.04.008

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Diagnostics of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) have recently been experiencing extensive modifications regarding the incorporation of next-generation sequencing (NGS) strategies into established diagnostic algorithms, classification and risk stratification systems, and minimal residual disease (MRD) detection. Considering the increasing arsenal of targeted therapies (e.g. FLT3 or IDH1/IDH2 inhibitors) for AML, timely and comprehensive molecular mutation screening has arrived in daily practice. Next-generation flow strategies allow for immunophenotypic minimal residual disease (MRD) monitoring with very high sensitivity. At the same time, standard diagnostic tools such as cytomorphology or conventional cytogenetics remain cornerstones for the diagnostic workup of myeloid malignancies. Herein, we summarize the most recent advances and new trends for the diagnostics of AML and MDS, discuss the difficulties, which accompany the integration of these new methods and their results into daily routine, and aim to define the role hemato-oncologists may play in this new diagnostic era.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene)

UniBE Contributor:

Banz Wälti, Yara; Bonadies, Nicolas; Pabst, Thomas and Bacher, Vera Ulrike

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0268-960X

Publisher:

Elsevier

Language:

English

Submitter:

Pierrette Durand Lüthi

Date Deposited:

20 Aug 2018 14:37

Last Modified:

21 Jan 2019 08:45

Publisher DOI:

10.1016/j.blre.2018.04.008

PubMed ID:

29728319

Uncontrolled Keywords:

Acute myeloid leukemia (AML) Interpretation of hematological results Myelodysplastic syndrome (MDS) New diagnostic era Next-generation sequencing (NGS) Versatility of current laboratory approaches

BORIS DOI:

10.7892/boris.119380

URI:

https://boris.unibe.ch/id/eprint/119380

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