Catheter-related infections: does the spectrum of microbial causes change over time? A nationwide surveillance study

Buetti, Niccolò; Atkinson, Andrew; Widmer, Andreas F; Kronenberg, Andreas; Marschall, Jonas (2018). Catheter-related infections: does the spectrum of microbial causes change over time? A nationwide surveillance study. BMJ open, 8(e023824), pp. 1-5. BMJ Publishing Group 10.1136/bmjopen-2018-023824

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OBJECTIVES: To estimate the incidence and epidemiology of catheter-related bloodstream infections (CRBSIs) on a national scale by using prospective epidemiological data from the Swiss Antibiotic Resistance Surveillance System (ANRESIS). DESIGN: Observational study. SETTING: National surveillance from 2008 to 2015 of acute hospitals in Switzerland. PARTICIPANTS: We included acute Swiss hospitals that sent blood cultures and catheter tip culture results on a regular basis during the entire study period to the ANRESIS database. OUTCOME MEASURE: A catheter-related bloodstream infection (termed 'modified CRBSI', mCRBSI) was defined as isolating the same microorganism with identical antibiogram from ≥1 blood cultures (performed ±7 days around the catheter removal) as the one recovered from the catheter tip. Incidence rates of mCRBSI were calculated per 1000 admissions. RESULTS: From 2008 to 2015, the mCRBSI incidence rate decreased from 0.83 to 0.58 episodes/1000 admissions (-6% per year, p<0.001). Coagulase-negative staphylococci, Staphylococcus aureus and fungi all exhibited decreasing trends, while rates of enterococci and Gram-negative bacteria remained stable. CONCLUSIONS: The overall incidence of mCRBSI in Switzerland is decreasing; however, the incidence of mCRBSI due to Enterococci and Gram-negative micro-organisms did not change over time. These pathogens may grow in importance in catheter-related infections, which would have clinical implications for the choice of empirical treatment.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Buetti, Niccolò Ivo Marco-Aurelio; Atkinson, Andrew; Kronenberg, Andreas Oskar and Marschall, Jonas

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2044-6055

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Andreas Oskar Kronenberg

Date Deposited:

28 Jan 2019 12:07

Last Modified:

22 Oct 2019 18:55

Publisher DOI:

10.1136/bmjopen-2018-023824

PubMed ID:

30580270

BORIS DOI:

10.7892/boris.123005

URI:

https://boris.unibe.ch/id/eprint/123005

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