Buetti, Niccolò; Atkinson, Andrew; Widmer, Andreas F; Kronenberg, Andreas; Marschall, Jonas (2018). Catheter-related infections: does the spectrum of microbial causes change over time? A nationwide surveillance study. BMJ open, 8(e023824), pp. 1-5. BMJ Publishing Group 10.1136/bmjopen-2018-023824
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OBJECTIVES:
To estimate the incidence and epidemiology of catheter-related bloodstream infections (CRBSIs) on a national scale by using prospective epidemiological data from the Swiss Antibiotic Resistance Surveillance System (ANRESIS).
DESIGN:
Observational study.
SETTING:
National surveillance from 2008 to 2015 of acute hospitals in Switzerland.
PARTICIPANTS:
We included acute Swiss hospitals that sent blood cultures and catheter tip culture results on a regular basis during the entire study period to the ANRESIS database.
OUTCOME MEASURE:
A catheter-related bloodstream infection (termed 'modified CRBSI', mCRBSI) was defined as isolating the same microorganism with identical antibiogram from ≥1 blood cultures (performed ±7 days around the catheter removal) as the one recovered from the catheter tip. Incidence rates of mCRBSI were calculated per 1000 admissions.
RESULTS:
From 2008 to 2015, the mCRBSI incidence rate decreased from 0.83 to 0.58 episodes/1000 admissions (-6% per year, p<0.001). Coagulase-negative staphylococci, Staphylococcus aureus and fungi all exhibited decreasing trends, while rates of enterococci and Gram-negative bacteria remained stable.
CONCLUSIONS:
The overall incidence of mCRBSI in Switzerland is decreasing; however, the incidence of mCRBSI due to Enterococci and Gram-negative micro-organisms did not change over time. These pathogens may grow in importance in catheter-related infections, which would have clinical implications for the choice of empirical treatment.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Buetti, Niccolò Ivo Marco-Aurelio, Atkinson, Andrew David, Kronenberg, Andreas Oskar, Marschall, Jonas |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
2044-6055 |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
Andreas Oskar Kronenberg |
Date Deposited: |
28 Jan 2019 12:07 |
Last Modified: |
05 Dec 2022 15:23 |
Publisher DOI: |
10.1136/bmjopen-2018-023824 |
PubMed ID: |
30580270 |
BORIS DOI: |
10.7892/boris.123005 |
URI: |
https://boris.unibe.ch/id/eprint/123005 |
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