GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn's disease

Körner, Meike; Rehmann, Ruth; Reubi, Jean-Claude (2012). GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn's disease. Molecular and cellular endocrinology, 364(1-2), pp. 46-53. Shannon: Elsevier Ireland 10.1016/j.mce.2012.08.008

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Peptide hormones of the glucagon-like peptide (GLP) family play an increasing clinical role, as reported for GLP-1 in diabetes therapy and insulinoma diagnostics. GLP-2, despite its known trophic and anti-inflammatory intestinal actions translated into preliminary clinical studies using the GLP-2 analogue teduglutide for treatment of short bowel syndrome and Crohn's disease, remains poorly characterized in terms of expression of its receptor in tissues of interest. Therefore, the GLP-2 receptor expression was assessed in 237 tumor and 148 non-neoplastic tissue samples with in vitro receptor autoradiography. A GLP-2 receptor expression was present in 68% of gastrointestinal stromal tumors (GIST). Furthermore, GLP-2 receptors were identified in the intestinal myenteric plexus, with significant up-regulation in active Crohn's disease. The GLP-2 receptors in GIST may be used for clinical applications like in vivo targeting with radiolabelled GLP-2 analogues for imaging and therapy. Moreover, the over-expressed GLP-2 receptor in the myenteric plexus may represent the morphological correlate of the clinical target of teduglutide in Crohn's disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Körner Jachertz, Meike and Reubi-Kattenbusch, Jean-Claude

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0303-7207

Publisher:

Elsevier Ireland

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

14 Oct 2019 15:43

Publisher DOI:

10.1016/j.mce.2012.08.008

PubMed ID:

22951144

Web of Science ID:

000311017200004

URI:

https://boris.unibe.ch/id/eprint/12473 (FactScience: 218819)

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