Ex vivo performance comparison of three percutaneous biopsy needle systems.

Krokidis, Miltiadis; Hungerbuehler, Martin; Hewer, Ekkehard; Heverhagen, Johannes; von Tengg-Kobligk, Hendrik (2019). Ex vivo performance comparison of three percutaneous biopsy needle systems. European radiology, 29(8), pp. 4044-4049. Springer-Verlag 10.1007/s00330-018-5960-7

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PURPOSE The aim of this study is to identify the micro-mechanical characteristics that define biopsy performance in normal ex vivo animal organs. MATERIALS AND METHODS Three biopsy systems with differences of needle external diameter, tray height and effective tray length were assessed. Sampling was performed in porcine liver and kidneys with commercially labelled 14G, 16G and 18G, using 2-cm throw needle systems. Five samples were obtained per needle size and per organ, and the experiment was repeated twice for a total of 90 biopsy cores. Samples were analysed and compared in terms of macroscopic aspect, sample length, weight and tissue architecture. RESULTS The system with the longest effective needle tray (system A) has shown significant superiority (p < 0.001) versus the other systems regarding the mean weight of tissue obtained for all needle sizes. Furthermore, the 14G needle of system A has shown superiority regarding the number of portal spaces and the 16G regarding the length of kidney fragments obtained. CONCLUSION The outcomes obtained with the different biopsy systems were not equal. The micro-mechanical characteristic that appears to influence the quantity and quality of the obtained tissue is the effective needle tray length and not the needle external diameter or the needle tray height. This information should be taken into account in the future design of biopsy needle systems, particularly when potentially used in the assessment of biomarkers and the characterisation of tumour micro-environment. KEY POINTS • The amount of obtained tissue mass is not the same among percutaneous biopsy needle systems. • There are different micro-mechanical characteristics that condition the amount of obtained tissue. • The micro-mechanical characteristic that offers more tissue mass for the same calibre is the effective length of the needle tray.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radiologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radiologie

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Krokidis, Miltiadis; Hungerbuehler, Martin; Hewer, Ekkehard; Heverhagen, Johannes and von Tengg-Kobligk, Hendrik

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0938-7994

Publisher:

Springer-Verlag

Language:

English

Submitter:

Isabelle Ursula Saurer

Date Deposited:

18 Feb 2019 14:49

Last Modified:

23 Oct 2019 13:46

Publisher DOI:

10.1007/s00330-018-5960-7

PubMed ID:

30643943

Uncontrolled Keywords:

Biopsy Kidney Liver Tissue

BORIS DOI:

10.7892/boris.124998

URI:

https://boris.unibe.ch/id/eprint/124998

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