The impact of CpG island methylator phenotype and microsatellite instability on tumour budding in colorectal cancer

Zlobec, Inti; Bihl, Michel P; Foerster, Anja; Rufle, Alex; Lugli, Alessandro (2012). The impact of CpG island methylator phenotype and microsatellite instability on tumour budding in colorectal cancer. Histopathology, 61(5), pp. 777-87. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2559.2012.04273.x

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In colorectal cancer, tumour budding, a process likened to epithelial mesenchymal transition, is an adverse prognostic factor which is rarely found in tumours with high-level microsatellite instability (MSI-H). Cases with MSI-H or high-level CpG island methylator phenotype (CIMP-H) have similar histomorphological features, yet seemingly opposite prognosis. We hypothesized that tumour budding is related to CIMP, thus partially explaining this prognostic difference.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Zlobec, Inti and Lugli, Alessandro

ISSN:

0309-0167

Publisher:

Blackwell Scientific Publications

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

06 Dec 2013 13:34

Publisher DOI:

10.1111/j.1365-2559.2012.04273.x

PubMed ID:

22803799

Web of Science ID:

000310482400004

URI:

https://boris.unibe.ch/id/eprint/12500 (FactScience: 218852)

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