Severe acute respiratory distress syndrome (ARDS) induced by human adenovirus B21: Report on 2 cases and literature review.

Pfortmüller, Carmen; Barbani, Maria Teresa; Schefold, Jörg Christian; Hage, Elias; Heim, Albert; Zimmerli, Stefan (2019). Severe acute respiratory distress syndrome (ARDS) induced by human adenovirus B21: Report on 2 cases and literature review. Journal of critical care, 51, pp. 99-104. Elsevier 10.1016/j.jcrc.2019.02.019

[img] Text
1-s2.0-S0883944118305926-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (980kB) | Request a copy

Severe pneumonia and ARDS caused by human adenovirus B21 infections (HAdV-B21) is a rare, but a devastating disease with rapid progression to multiorgan failure and death. However, only a few cases were reported so far. Infections appear associated with increased disease severity and higher mortality in infected critically ill patients. Possible factors contributing to infection are underlying psychiatric disease resulting in institutionalization of respective patients, and polytoxicomania. Controlled data on the therapy of severe adenovirus infections are lacking and remains experimental. In conclusion, data on HAdV-B21 infections causing severe pneumonia or ARDS are scarce. Controlled clinical trials on the therapy of adenovirus pneumonia are non existent and thus there is no established therapy so far. ICU physicians should be aware of this potentially devastating disease and further studies are needed.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Pfortmüller, Carmen; Schefold, Jörg Christian and Zimmerli, Stefan


600 Technology > 610 Medicine & health








Annelies Luginbühl

Date Deposited:

23 Apr 2019 11:10

Last Modified:

23 Oct 2019 11:28

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Critical illness HAdV-B21 Respiratory failure Viral 21B




Actions (login required)

Edit item Edit item
Provide Feedback