Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection.

Alves, Marco; Vielle, Nathalie Jane; Thiel, Volker Earl; Pfänder, Stephanie (2018). Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection. Viruses, 10(11) Molecular Diversity Preservation International MDPI 10.3390/v10110593

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Zika virus recently re-emerged and caused global outbreaks mainly in Central Africa, Southeast Asia, the Pacific Islands and in Central and South America. Even though there is a declining trend, the virus continues to spread throughout different geographical regions of the world. Since its re-emergence in 2015, massive advances have been made regarding our understanding of clinical manifestations, epidemiology, genetic diversity, genomic structure and potential therapeutic intervention strategies. Nevertheless, treatment remains a challenge as there is no licensed effective therapy available. This review focuses on the recent advances regarding research models, as well as available experimental tools that can be used for the identification and characterization of potential antiviral targets and therapeutic intervention strategies.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Alves, Marco; Vielle, Nathalie Jane; Thiel, Volker Earl and Pfänder, Stephanie

Subjects:

600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1999-4915

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

04 Jun 2019 12:37

Last Modified:

04 Jun 2019 12:46

Publisher DOI:

10.3390/v10110593

PubMed ID:

30380760

Uncontrolled Keywords:

Zika virus antivirals research models and tools therapeutics

BORIS DOI:

10.7892/boris.127521

URI:

https://boris.unibe.ch/id/eprint/127521

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