Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma

Djavaheri-Mergny, Mojgan; Giuriato, Sylvie; Tschan, Mario; Humbert, Magali (2019). Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma. Cells, 8(2) MDPI 10.3390/cells8020103

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Haematopoiesis is a tightly orchestrated process where a pool of hematopoietic stem and progenitor cells (HSPCs) with high self-renewal potential can give rise to both lymphoid and myeloid lineages. The HSPCs pool is reduced with ageing resulting in few HSPC clones maintaining haematopoiesis thereby reducing blood cell diversity, a phenomenon called clonal haematopoiesis. Clonal expansion of HSPCs carrying specific genetic mutations leads to increased risk for haematological malignancies. Therefore, it comes as no surprise that hematopoietic tumours develop in higher frequency in elderly people. Unfortunately, elderly patients with leukaemia or lymphoma still have an unsatisfactory prognosis compared to younger ones highlighting the need to develop more efficient therapies for this group of patients. Growing evidence indicates that macroautophagy (hereafter referred to as autophagy) is essential for health and longevity. This review is focusing on the role of autophagy in normal haematopoiesis as well as in leukaemia and lymphoma development. Attenuated autophagy may support early hematopoietic neoplasia whereas activation of autophagy in later stages of tumour development and in response to a variety of therapies rather triggers a pro-tumoral response. Novel insights into the role of autophagy in haematopoiesis will be discussed in light of designing new autophagy modulating therapies in hematopoietic cancers.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Tumour Pathology

UniBE Contributor:

Tschan, Mario and Humbert, Magali

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2073-4409

Publisher:

MDPI

Language:

English

Submitter:

Magali Humbert

Date Deposited:

15 Jul 2019 15:32

Last Modified:

24 Oct 2019 22:28

Publisher DOI:

10.3390/cells8020103

PubMed ID:

30704144

Uncontrolled Keywords:

ageing; haematopoiesis; leukaemia; lymphomas; macroautophagy; therapy response

BORIS DOI:

10.7892/boris.130226

URI:

https://boris.unibe.ch/id/eprint/130226

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