Secondary Active Transporters.

Bosshart, Patrick; Fotiadis, Dimitrios (2019). Secondary Active Transporters. Sub-cellular biochemistry, 92, pp. 275-299. Springer 10.1007/978-3-030-18768-2_9

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Transport of solutes across biological membranes is essential for cellular life. This process is mediated by membrane transport proteins which move nutrients, waste products, certain drugs and ions into and out of cells. Secondary active transporters couple the transport of substrates against their concentration gradients with the transport of other solutes down their concentration gradients. The alternating access model of membrane transporters and the coupling mechanism of secondary active transporters are introduced in this book chapter. Structural studies have identified typical protein folds for transporters that we exemplify by the major facilitator superfamily (MFS) and LeuT folds. Finally, substrate binding and substrate translocation of the transporters LacY of the MFS and AdiC of the amino acid-polyamine-organocation (APC) superfamily are described.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Faculty Institutions > NCCR TransCure
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Bosshart, Patrick and Fotiadis, Dimitrios José

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0306-0225

Publisher:

Springer

Language:

English

Submitter:

Barbara Järmann-Bangerter

Date Deposited:

26 Sep 2019 10:11

Last Modified:

24 Oct 2019 05:20

Publisher DOI:

10.1007/978-3-030-18768-2_9

PubMed ID:

31214990

Uncontrolled Keywords:

Alternating access model Amino acid-polyamine-organocation superfamily Major facilitator superfamily Membrane transporter Secondary active transporter Transport mechanism Transporter fold

BORIS DOI:

10.7892/boris.133482

URI:

https://boris.unibe.ch/id/eprint/133482

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