Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish

Sande-Melón, Marcos; Marques, Inês J.; Galardi-Castilla, María; Langa, Xavier; Pérez-López, María; Botos, Marius-Alexandru; Sánchez-Iranzo, Héctor; Guzmán-Martínez, Gabriela; Ferreira Francisco, David Miguel; Pavlinic, Dinko; Benes, Vladimir; Bruggmann, Rémy; Mercader Huber, Nadia Isabel (2019). Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish. Cell reports, 29(4), pp. 1041-1054. Cell Press 10.1016/j.celrep.2019.09.041

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During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identify a subset of preexistent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded after cryoinjury. Genetic ablation of sox10+ cardiomyocytes impairs cardiac regeneration, revealing that these cells play a role in heart regeneration.

Item Type:

Journal Article (Original Article)

Division/Institute:

09 Interdisciplinary Units > Microscopy Imaging Center (MIC)
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Sande Melon, Marcos; dos Santos Marques, Ines Joao; Langa Oliva, Javier; Botos, Marius-Alexandru; Ferreira Francisco, David Miguel; Bruggmann, Rémy and Mercader Huber, Nadia Isabel

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

2211-1247

Publisher:

Cell Press

Language:

English

Submitter:

Nadia Isabel Mercader Huber

Date Deposited:

10 Dec 2019 14:51

Last Modified:

10 Dec 2019 14:51

Publisher DOI:

10.1016/j.celrep.2019.09.041

PubMed ID:

31644901

BORIS DOI:

10.7892/boris.135133

URI:

https://boris.unibe.ch/id/eprint/135133

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