Karlen, Hélène; Yousefi, Shida; Simon, Hans-Uwe; Simon, Dagmar (2020). IL-15 Expression Pattern in Atopic Dermatitis. International archives of allergy and immunology, 181(6), pp. 417-421. Karger 10.1159/000508515
Full text not available from this repository. (Request a copy)BACKGROUND
An increased expression of interleukin (IL)-15, a cytokine with a key role in stimulating innate and adaptive immune cells, such as dendritic cells (DC), natural killer cells, and T cells, has been observed in infectious and inflammatory diseases, including autoimmune diseases as well as cancer. Atopic dermatitis (AD) is a common inflammatory skin disease characterized by a type 2 immune response.
OBJECTIVE
To explore the expression of IL-15 and its pattern in AD skin.
METHOD
Immunofluorescence staining was performed on skin specimens of AD skin, nonlesional AD skin (AD NL), and normal skin (NS) using antibodies directed against IL-15 and CD3, mast cell tryptase, eosinophil cationic protein, CD68, CD11b, CD1a, and vimentin.
RESULTS
A significantly higher IL-15 expression in AD and AD NL was observed in both the epidermis (p = 0.0003) and the dermis (p = 0.0154) as compared to NS. Cells expressing IL-15 were mainly keratinocytes, CD1a+ DC, CD11b+ DC, CD68+ macrophages, and vimentin+ fibroblasts. In AD, an increase in the relative numbers of IL-15 expressing CD1a+ DC, macrophages, and fibroblasts was noted.
CONCLUSION
Our results demonstrate an expression of IL-15 in AD similar to that of eosinophilic esophagitis which is also a type 2 disease. IL-15 may serve as a therapeutic target for AD.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology |
UniBE Contributor: |
Yousefi, Shida, Simon, Hans-Uwe, Simon, Dagmar |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1018-2438 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Sabrina Cookman |
Date Deposited: |
10 Dec 2020 15:35 |
Last Modified: |
05 Dec 2022 15:38 |
Publisher DOI: |
10.1159/000508515 |
PubMed ID: |
32422638 |
Uncontrolled Keywords: |
Atopic dermatitis Dendritic cell Fibroblast Interleukin 15 Keratinocyte |
URI: |
https://boris.unibe.ch/id/eprint/144323 |
Actions (login required)
 |
Edit item |