Loss to follow-up correction increased mortality estimates in HIV-positive people on antiretroviral therapy in Mozambique.

Anderegg, Nanina; Hector, Jonas; Jefferys, Laura F; Burgos-Soto, Juan; Hobbins, Michael A; Ehmer, Jochen; Meier, Lukas; Maathuis, Marloes H; Egger, Matthias (2020). Loss to follow-up correction increased mortality estimates in HIV-positive people on antiretroviral therapy in Mozambique. Journal of clinical epidemiology, 128, pp. 83-92. Elsevier 10.1016/j.jclinepi.2020.08.012

Preview	Text Anderegg JClinEpidemiol 2020_AAM.pdf - Accepted Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (2MB) | Preview
	Text Anderegg_JClinEpidemiol_2020.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB)

OBJECTIVES

People living with HIV (PLWH) on antiretroviral therapy (ART) may be lost to follow-up (LTFU), which hampers the assessment of outcomes. We estimated mortality for patients starting ART in a rural region in sub-Saharan Africa and examined risk factors for death, correcting for LTFU.

STUDY DESIGN AND SETTING

We analysed data from Ancuabe, Mozambique, where patients LTFU are traced by phone and home visits. We used cumulative incidence functions to estimate mortality and LTFU. To correct for LTFU, we revised outcomes based on tracing data using different inverse probability weights (maximum likelihood [ML], Ridge regression or Bayesian model averaging [BMA]). We fitted competing risk models to identify risk factors for death and LTFU.

RESULTS

Analyses included 4492 patients; during 8152 person-years of follow-up, 486 patients died, 2375 were LTFU, 752 were traced, and 603 were found. At 4 years after starting ART, observed mortality was 11.9% (95% CI 10.9-13.0) but 23.5% (19.8- 28.0), 21.6% (18.7-25.0) and 23.3% (19.7-27.6) after correction with ML, Ridge and BMA weights, respectively. Risk factors for death included male sex, lower CD4 cell counts and more advanced clinical stage.

CONCLUSION

In ART programmes with substantial LTFU, mortality estimates need to take LTFU into account.

Interest & Impact

Downloads

123 since deposited on 01 Sep 2020
23 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item