SARS-CoV-2 Infection During Induction Chemotherapy in a Child With High-risk T-Cell Acute Lymphoblastic Leukemia (T-ALL).

Dantonello, Tobias M.; Kartal-Kaess, Mutlu; Aebi, Christoph; Suter-Riniker, Franziska; Busch, Jasmin D.; Kubetzko, Susanne; Bourquin, Jean-Pierre; Roessler, Jochen (2020). SARS-CoV-2 Infection During Induction Chemotherapy in a Child With High-risk T-Cell Acute Lymphoblastic Leukemia (T-ALL). (In Press). Journal of pediatric hematology/oncology Wolters Kluwer Health 10.1097/MPH.0000000000001943

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The clinical course of SARS-CoV-2 infection (COVID-19) in children with hematologic malignancies is unclear. We describe the diagnosis, treatment and outcome of a 4-year-old boy with high-risk acute lymphoblastic leukemia and COVID-19. Regardless of immunosuppressive induction chemotherapy his symptoms remained moderate. He received only supportive treatment. Seroconversion occurred in a similar period as in immunocompetent adults. Despite prolonged myelosuppression he did neither acquire secondary infections nor did the treatment delay caused by the infection have a measurable negative impact on the residual disease of acute lymphoblastic leukemia. Intriguingly, residual leukemia even decreased even though he did not receive any antileukemic therapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Haematology/Oncology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Dantonello, Tobias; Kartal-Kaess, Mutlu; Aebi, Christoph; Suter, Franziska Marta; Busch, Jasmin D. and Rössler, Jochen Karl

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1536-3678

Publisher:

Wolters Kluwer Health

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

15 Sep 2020 15:33

Last Modified:

04 Nov 2020 10:36

Publisher DOI:

10.1097/MPH.0000000000001943

PubMed ID:

32925396

BORIS DOI:

10.7892/boris.146536

URI:

https://boris.unibe.ch/id/eprint/146536

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