Dantonello, Tobias M.; Kartal-Kaess, Mutlu; Aebi, Christoph; Suter-Riniker, Franziska; Busch, Jasmin D.; Kubetzko, Susanne; Bourquin, Jean-Pierre; Roessler, Jochen (2021). SARS-CoV-2 Infection During Induction Chemotherapy in a Child With High-risk T-Cell Acute Lymphoblastic Leukemia (T-ALL). Journal of pediatric hematology/oncology, 43(6), e804-e807. Wolters Kluwer Health 10.1097/MPH.0000000000001943
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The clinical course of SARS-CoV-2 infection (COVID-19) in children with hematologic malignancies is unclear. We describe the diagnosis, treatment and outcome of a 4-year-old boy with high-risk acute lymphoblastic leukemia and COVID-19. Regardless of immunosuppressive induction chemotherapy his symptoms remained moderate. He received only supportive treatment. Seroconversion occurred in a similar period as in immunocompetent adults. Despite prolonged myelosuppression he did neither acquire secondary infections nor did the treatment delay caused by the infection have a measurable negative impact on the residual disease of acute lymphoblastic leukemia. Intriguingly, residual leukemia even decreased even though he did not receive any antileukemic therapy.
Item Type: |
Journal Article (Further Contribution) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Haematology/Oncology 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Dantonello, Tobias, Kartal-Kaess, Mutlu, Aebi, Christoph, Suter, Franziska Marta, Busch, Jasmin D., Rössler, Jochen Karl |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1536-3678 |
Publisher: |
Wolters Kluwer Health |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
15 Sep 2020 15:33 |
Last Modified: |
05 Dec 2022 15:40 |
Publisher DOI: |
10.1097/MPH.0000000000001943 |
PubMed ID: |
32925396 |
BORIS DOI: |
10.7892/boris.146536 |
URI: |
https://boris.unibe.ch/id/eprint/146536 |
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