IgA Triggers Cell Death of Neutrophils When Primed by Inflammatory Mediators.

Wehrli, Marc; Schneider, Christoph; Cortinas-Elizondo, Fabiola; Verschoor, Daniëlle; Frias Boligan, Kayluz; Adams, Olivia Joan; Hlushchuk, Ruslan; Engelmann, Christine; Daudel, Fritz; Villiger, Peter M.; Seibold, Frank; Yawalkar, Nikhil; Vonarburg, Cédric; Miescher, Sylvia; Lötscher, Marius; Kaufmann, Thomas; Münz, Christian; Mueller, Christoph; Djonov, Valentin; Simon, Hans-Uwe; ... (2020). IgA Triggers Cell Death of Neutrophils When Primed by Inflammatory Mediators. Journal of immunology, 205(10), pp. 2640-2648. American Association of Immunologists 10.4049/jimmunol.1900883

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IVIG preparations consisting of pooled IgG are increasingly used for the treatment of autoimmune diseases. IVIG is known to regulate the viability of immune cells, including neutrophils. We report that plasma-derived IgA efficiently triggers death of neutrophils primed by cytokines or TLR agonists. IgA-mediated programmed neutrophil death was PI3K-, p38 MAPK-, and JNK-dependent and evoked anti-inflammatory cytokines in macrophage cocultures. Neutrophils from patients with acute Crohn's disease, rheumatoid arthritis, or sepsis were susceptible to both IgA- and IVIG-mediated death. In contrast to IVIG, IgA did not promote cell death of quiescent neutrophils. Our findings suggest that plasma-derived IgA might provide a therapeutic option for the treatment of neutrophil-associated inflammatory disorders.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology

UniBE Contributor:

Verschoor, Daniëlle; Frias Boligan, Kayluz; Adams, Olivia Joan; Hlushchuk, Ruslan; Villiger, Peter; Yawalkar, Nikhil; Kaufmann, Thomas; Müller, Christoph; Djonov, Valentin Georgiev; Simon, Hans-Uwe and von Gunten, Stephan

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0022-1767

Publisher:

American Association of Immunologists

Language:

English

Submitter:

Andrea Stettler

Date Deposited:

29 Oct 2020 10:44

Last Modified:

04 Jan 2021 15:48

Publisher DOI:

10.4049/jimmunol.1900883

PubMed ID:

33008951

BORIS DOI:

10.7892/boris.147625

URI:

https://boris.unibe.ch/id/eprint/147625

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