Longitudinal Course of Clinical Lung Clearance Index in Children with Cystic Fibrosis.

Frauchiger, Bettina S; Binggeli, Severin; Yammine, Sophie; Spycher, Ben; Krüger, Linn; Ramsey, Kathryn A; Latzin, Philipp (2020). Longitudinal Course of Clinical Lung Clearance Index in Children with Cystic Fibrosis. (In Press). European respiratory journal European Respiratory Society 10.1183/13993003.02686-2020

[img] Text
Frauchiger_EurRespirJ_2020_AAM.pdf - Accepted Version
Restricted to registered users only until 25 June 2021.
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

RATIONALE

While lung clearance index (LCI) is a sensitive marker of small airway disease in individuals with cystic fibrosis (CF), less is known about longitudinal changes in LCI during routine clinical surveillance.

OBJECTIVES

To describe the longitudinal course of LCI in children with CF during routine clinical surveillance and assess influencing factors.

METHODS

Children with CF aged 3-18 years performed LCI measurements every 3 months as part of routine clinical care between 2011 and 2018. We recorded clinical data at every visit. We used a multilevel mixed-effect model to determine changes in LCI over time and identify clinical factors that influence LCI course.

MEASUREMENTS AND MAIN RESULTS

We collected LCI from 1204 visits (3603 trials) in 78 participants, of which 907 visits had acceptable LCI data. The average unadjusted increase in LCI for the entire population was 0.29 LCI units·year-1 (95% CI 0.20-0.38). The increase in LCI was more pronounced in adolescence, with 0.41 units·year-1 (95% CI 0.27-0.54). Colonisation with either Pseudomonas aeruginosa or Aspergillus fumigatus, pulmonary exacerbations, CF-related diabetes, and bronchopulmonary aspergillosis were associated with a higher increase in LCI over time. Adjusting for clinical risk factors reduced the increase in LCI over time to 0.24 LCI units·year-1 (95% CI 0.16-0.33).

CONCLUSION

LCI measured during routine clinical surveillance is associated with underlying disease progression in children with CF. An increased change in LCI over time should prompt further diagnostic intervention.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Frauchiger, Bettina; Binggeli, Severin; Yammine, Sophie; Spycher, Ben; Krüger, Linn; Ramsey, Kathryn Angela and Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0903-1936

Publisher:

European Respiratory Society

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

04 Jan 2021 16:53

Last Modified:

13 Mar 2021 20:00

Publisher DOI:

10.1183/13993003.02686-2020

PubMed ID:

33361098

BORIS DOI:

10.48350/150603

URI:

https://boris.unibe.ch/id/eprint/150603

Actions (login required)

Edit item Edit item
Provide Feedback