SLC16 Family: From Atomic Structure to Human Disease.

Bosshart, Patrick D.; Charles, Roch-Philippe; Garibsingh, Rachel-Ann A; Schlessinger, Avner; Fotiadis, Dimitrios (2021). SLC16 Family: From Atomic Structure to Human Disease. Trends in biochemical sciences, 46(1), pp. 28-40. Elsevier Current Trends 10.1016/j.tibs.2020.07.005

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The solute carrier 16 (SLC16) family represents a diverse group of membrane proteins mediating the transport of monocarboxylates across biological membranes. Family members show a variety of functional roles ranging from nutrient transport and intracellular pH regulation to thyroid hormone homeostasis. Changes in the expression levels and transport function of certain SLC16 transporters are manifested in severe health disorders including cancer, diabetes, and neurological disorders. L-Lactate-transporting SLC16 family members play essential roles in the metabolism of certain tumors and became validated drug targets. This review illuminates the SLC16 family under a new light using structural information obtained from a SLC16 homolog. Furthermore, the role of these transporters in cancer metabolism and how their inhibition can contribute to anticancer therapy are discussed.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Faculty Institutions > NCCR TransCure
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Bosshart, Patrick; Charles, Roch-Philippe and Fotiadis, Dimitrios José

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0968-0004

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Barbara Järmann-Bangerter

Date Deposited:

18 Jan 2021 09:53

Last Modified:

18 Jan 2021 09:53

Publisher DOI:

10.1016/j.tibs.2020.07.005

PubMed ID:

32828650

Uncontrolled Keywords:

L-lactate Warburg effect membrane protein metabolic symbiosis monocarboxylate transporter solute carrier 16 family

BORIS DOI:

10.48350/150864

URI:

https://boris.unibe.ch/id/eprint/150864

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