The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study.

Surial, Bernard; Bertholet, Nicolas; Daeppen, Jean-Bernard; Darling, Katharine E A; Calmy, Alexandra; Günthard, Huldrych F; Stöckle, Marcel; Bernasconi, Enos; Schmid, Patrick; Rauch, Andri; Furrer, Hansjakob; Wandeler, Gilles (2021). The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study. Journal of clinical medicine, 10(2), p. 295. MDPI 10.3390/jcm10020295

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Whereas excessive alcohol consumption increases liver disease incidence and mortality, evidence on the risk associated with specific drinking patterns is emerging. We assessed the impact of binge drinking on mortality and liver disease in the Swiss HIV Cohort Study. All participants with follow-up between 2013 and 2020 were categorized into one of four drinking pattern groups: "abstinence", "non-hazardous drinking", "hazardous but not binge drinking" (Alcohol Use Disorder Identification Test Consumption [AUDIT-C] score ≥ 3 in women and ≥4 in men), and "binge drinking" (≥6 drinks/occasion more than monthly). We estimated adjusted incidence rate ratios (aIRR) for all-cause mortality, liver-related mortality and liver-related events using multivariable quasi-Poisson regression. Among 11,849 individuals (median follow-up 6.8 years), 470 died (incidence rate 7.1/1000 person-years, 95% confidence interval [CI] 6.5-7.8), 37 experienced a liver-related death (0.6/1000, 0.4-0.8), and 239 liver-related events occurred (3.7/1000, 3.2-4.2). Compared to individuals with non-hazardous drinking, those reporting binge drinking were more likely to die (all-cause mortality: aIRR 1.9, 95% CI 1.3-2.7; liver-related mortality: 3.6, 0.9-13.9) and to experience a liver-related event (3.8, 2.4-5.8). We observed no difference in outcomes between participants reporting non-hazardous and hazardous without binge drinking. These findings highlight the importance of assessing drinking patterns in clinical routine.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Surial, Bernard; Rauch, Andri; Furrer, Hansjakob and Wandeler, Gilles

Subjects:

300 Social sciences, sociology & anthropology > 360 Social problems & social services
600 Technology > 610 Medicine & health

ISSN:

2077-0383

Publisher:

MDPI

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

17 Feb 2021 14:42

Last Modified:

13 Mar 2021 20:35

Publisher DOI:

10.3390/jcm10020295

PubMed ID:

33466907

Uncontrolled Keywords:

HIV alcohol binge drinking liver-related outcomes mortality

BORIS DOI:

10.48350/151861

URI:

https://boris.unibe.ch/id/eprint/151861

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