Primordial GATA6 macrophages function as extravascular platelets in sterile injury.

Zindel, J; Peiseler, M; Hossain, M; Deppermann, C; Lee, W Y; Haenni, B; Zuber, B; Deniset, J F; Surewaard, B G J; Candinas, D; Kubes, P (2021). Primordial GATA6 macrophages function as extravascular platelets in sterile injury. Science, 371(6533) American Association for the Advancement of Science 10.1126/science.abe0595

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Most multicellular organisms have a major body cavity that harbors immune cells. In primordial species such as purple sea urchins, these cells perform phagocytic functions but are also crucial in repairing injuries. In mammals, the peritoneal cavity contains large numbers of resident GATA6+ macrophages, which may function similarly. However, it is unclear how cavity macrophages suspended in the fluid phase (peritoneal fluid) identify and migrate toward injuries. In this study, we used intravital microscopy to show that cavity macrophages in fluid rapidly form thrombus-like structures in response to injury by means of primordial scavenger receptor cysteine-rich domains. Aggregates of cavity macrophages physically sealed injuries and promoted rapid repair of focal lesions. In iatrogenic surgical situations, these cavity macrophages formed extensive aggregates that promoted the growth of intra-abdominal scar tissue known as peritoneal adhesions.

Item Type:

Journal Article (Original Article)

Division/Institute:

09 Interdisciplinary Units > Microscopy Imaging Center (MIC)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

UniBE Contributor:

Zindel, Joel; Haenni, Beat; Zuber, Benoît and Candinas, Daniel

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0036-8075

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Benoît Zuber

Date Deposited:

19 Apr 2021 11:56

Last Modified:

19 Apr 2021 12:05

Publisher DOI:

10.1126/science.abe0595

PubMed ID:

33674464

BORIS DOI:

10.48350/153721

URI:

https://boris.unibe.ch/id/eprint/153721

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