Primordial GATA6 macrophages function as extravascular platelets in sterile injury.

Zindel, J; Peiseler, M; Hossain, M; Deppermann, C; Lee, W Y; Haenni, B; Zuber, B; Deniset, J F; Surewaard, B G J; Candinas, D; Kubes, P (2021). Primordial GATA6 macrophages function as extravascular platelets in sterile injury. Science, 371(6533) American Association for the Advancement of Science 10.1126/science.abe0595

	Text eabe0595.full.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Author holds Copyright Download (7MB)
Preview	Text abe0595_ArticleContent_preprint.pdf - Accepted Version Available under License Publisher holds Copyright. Download (61MB) | Preview

Most multicellular organisms have a major body cavity that harbors immune cells. In primordial species such as purple sea urchins, these cells perform phagocytic functions but are also crucial in repairing injuries. In mammals, the peritoneal cavity contains large numbers of resident GATA6+ macrophages, which may function similarly. However, it is unclear how cavity macrophages suspended in the fluid phase (peritoneal fluid) identify and migrate toward injuries. In this study, we used intravital microscopy to show that cavity macrophages in fluid rapidly form thrombus-like structures in response to injury by means of primordial scavenger receptor cysteine-rich domains. Aggregates of cavity macrophages physically sealed injuries and promoted rapid repair of focal lesions. In iatrogenic surgical situations, these cavity macrophages formed extensive aggregates that promoted the growth of intra-abdominal scar tissue known as peritoneal adhesions.

Interest & Impact

Downloads

22 since deposited on 19 Apr 2021
3 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item