Tailored liposomal nanotraps for the treatment of Streptococcal infections.

Besançon, Hervé; Babiychuk, Viktoriia; Larpin, Yu; Köffel, René; Schittny, Dominik; Brockhus, Lara; Hathaway, Lucy J.; Sendi, Parham; Draeger, Annette; Babiichuk, Eduard (2021). Tailored liposomal nanotraps for the treatment of Streptococcal infections. Journal of nanobiotechnology, 19(1), p. 46. BioMed Central 10.1186/s12951-021-00775-x

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BACKGROUND

Streptococcal infections are associated with life-threatening pneumonia and sepsis. The rise in antibiotic resistance calls for novel approaches to treat bacterial diseases. Anti-virulence strategies promote a natural way of pathogen clearance by eliminating the advantage provided to bacteria by their virulence factors. In contrast to antibiotics, anti-virulence agents are less likely to exert selective evolutionary pressure, which is a prerequisite for the development of drug resistance. As part of their virulence mechanism, many bacterial pathogens secrete cytolytic exotoxins (hemolysins) that destroy the host cell by destabilizing their plasma membrane. Liposomal nanotraps, mimicking plasmalemmal structures of host cells that are specifically targeted by bacterial toxins are being developed in order to neutralize-by competitive sequestration-numerous exotoxins.

RESULTS

In this study, the liposomal nanotrap technology is further developed to simultaneously neutralize the whole palette of cytolysins produced by Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis-pathogens that can cause life-threatening streptococcal toxic shock syndrome. We show that the mixture of liposomes containing high amounts of cholesterol and liposomes composed exclusively of choline-containing phospholipids is fully protective against the combined action of exotoxins secreted by these pathogens.

CONCLUSIONS

Unravelling the universal mechanisms that define targeting of host cells by streptococcal cytolysins paves the way for a broad-spectrum anti-toxin therapy that can be applied without a diagnostic delay for the treatment of bacterial infections including those caused by antibiotic-resistant pathogens.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Cell Biology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Besançon, Hervé; Babiychuk, Viktoriia; Larpin, Yu Noël; Köffel, René; Schittny, Dominik Christian; Brockhus, Lara Aurora; Hathaway, Lucy Jane; Sendi, Parham; Draeger, Annette and Babiichuk, Eduard

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1477-3155

Publisher:

BioMed Central

Language:

English

Submitter:

Hervé Besançon

Date Deposited:

07 May 2021 13:11

Last Modified:

09 May 2021 03:04

Publisher DOI:

10.1186/s12951-021-00775-x

PubMed ID:

33588835

Uncontrolled Keywords:

Infection Liposome Nanotrap Streptococcus Toxin

BORIS DOI:

10.48350/155496

URI:

https://boris.unibe.ch/id/eprint/155496

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