Naguleswaran, Arunasalam; Alves Fernandes, Paula; Bevkal Subramanyaswamy, Shubha; Rehmann, Ruth; Nicholson, Pamela; Roditi, Isabel (2021). Draft genome of Trypanosoma b. brucei EATRO1125 (AnTaR1 serodeme) strain [Dataset]. In: EATRO1125 (AnTaR1 serodeme) pseudo chromosomes.
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Archive (Draft genome sequence)
Typanosoma_brucei_EATRO1125_pseudochr.fasta.gz - Other Available under License BORIS Standard License. Download (15MB) |
Trypanosoma brucei spp, unicellular parasites causing human and animal trypanosomiasis, are transmitted between mammals by tsetse flies. Periodic changes in variant surface glycoproteins (VSG) which form the parasite coat in the mammal, allow them to evade the host immune response. Different isolates of T. brucei show heterogeneity in their repertoires of VSG genes and have single nucleotide polymorphisms that can impact on genome editing. T. b. brucei EATRO1125 (AnTaR1 serodeme) is an isolate that is used increasingly often because it is pleomorphic in mammals and fly transmissible, two characteristics that have been lost by the most commonly used laboratory stocks. We present a draft genome of EATRO1125, including contigs for the intermediate and mini-chromosomes that serve as repositories of VSG genes.
Item Type: |
Dataset |
|---|---|
Division/Institute: |
09 Interdisciplinary Units > Next Generation Sequencing (NGS) Platform 08 Faculty of Science > Department of Biology > Institute of Cell Biology > Parasitologie 08 Faculty of Science > Department of Biology > Institute of Cell Biology |
UniBE Contributor: |
Naguleswaran, Arunasalam, Alves Fernandes, Paula, Bevkal Subramanyaswamy, Shubha, Rehmann, Ruth, Nicholson, Pamela, Roditi, Isabel |
Subjects: |
500 Science > 570 Life sciences; biology |
Language: |
English |
Submitter: |
Arunasalam Naguleswaran |
Date Deposited: |
26 Apr 2021 08:35 |
Last Modified: |
05 Dec 2022 15:50 |
BORIS DOI: |
10.48350/156011 |
URI: |
https://boris.unibe.ch/id/eprint/156011 |
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