Prevalence and significance of bacterial contamination of autologous stem cell products.

Damonti, Lauro; Buetti, Niccolò; Droz, Sara; Bacher, Ulrike; Pabst, Thomas; Mansouri Taleghani, Behrouz; Baerlocher, Gabriela Maria; Marschall, Jonas (2021). Prevalence and significance of bacterial contamination of autologous stem cell products. (In Press). The journal of hospital infection Elsevier 10.1016/j.jhin.2021.04.006

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There is limited and conflicting information on the prevalence of the contamination of hematopoietic stem and progenitor cell products (HPCPs) and their optimal management remains unclear. We reviewed the microbial surveillance data of HPCPs collected between 01/2002 and 12/2019 for autologous transplantation at our institution to determine the prevalence of microbial contamination and the potential infectious complications among recipients. Among 3935 HPCPs, 25 (0.6%) were contaminated. Ultimately, 22 patients received contaminated grafts, with a preemptive antimicrobial therapy initiated in 6/22. None developed subsequent infectious complications. Our data suggest that microbial contamination of autologous HPCPs and associated adverse outcomes are rare.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Damonti, Lauro; Buetti, Niccolò Ivo Marco-Aurelio; Droz, Sara Christine; Bacher, Vera Ulrike; Pabst, Thomas Niklaus; Mansouri Taleghani, Behrouz; Baerlocher, Gabriela Maria and Marschall, Jonas

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1532-2939

Publisher:

Elsevier

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

29 Apr 2021 13:36

Last Modified:

29 Apr 2021 13:36

Publisher DOI:

10.1016/j.jhin.2021.04.006

PubMed ID:

33864895

Uncontrolled Keywords:

autologous stem cell products contamination hematopoietic stem and progenitor cell products

BORIS DOI:

10.48350/156062

URI:

https://boris.unibe.ch/id/eprint/156062

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