Damonti, Lauro; Buetti, Niccolò; Droz, Sara; Bacher, Ulrike; Pabst, Thomas; Mansouri Taleghani, Behrouz; Baerlocher, Gabriela Maria; Marschall, Jonas (2021). Prevalence and significance of bacterial contamination of autologous stem cell products. The journal of hospital infection, 114, pp. 175-179. Elsevier 10.1016/j.jhin.2021.04.006
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1-s2.0-S0195670121001572-main.pdf - Accepted Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (483kB) | Preview |
There is limited and conflicting information on the prevalence of the contamination of hematopoietic stem and progenitor cell products (HPCPs) and their optimal management remains unclear. We reviewed the microbial surveillance data of HPCPs collected between 01/2002 and 12/2019 for autologous transplantation at our institution to determine the prevalence of microbial contamination and the potential infectious complications among recipients. Among 3935 HPCPs, 25 (0.6%) were contaminated. Ultimately, 22 patients received contaminated grafts, with a preemptive antimicrobial therapy initiated in 6/22. None developed subsequent infectious complications. Our data suggest that microbial contamination of autologous HPCPs and associated adverse outcomes are rare.
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