Bayesian brain in tinnitus: Computational modeling of three perceptual phenomena using a modified Hierarchical Gaussian Filter

Hu, Suyi; Hall, Deborah A.; Zubler, Frédéric; Sznitman, Raphael; Anschütz, Lukas; Caversaccio, Marco; Wimmer, Wilhelm (2021). Bayesian brain in tinnitus: Computational modeling of three perceptual phenomena using a modified Hierarchical Gaussian Filter. Hearing research, 410(108338), p. 108338. Elsevier 10.1016/j.heares.2021.108338

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Recently, Bayesian brain-based models emerged as a possible composite of existing theories, providing an universal explanation of tinnitus phenomena. Yet, the involvement of multiple synergistic mechanisms complicates the identification of behavioral and physiological evidence. To overcome this, an empirically tested computational model could support the evaluation of theoretical hypotheses by intrinsically encompassing different mechanisms. The aim of this work was to develop a generative computational tinnitus perception model based on the Bayesian brain concept. The behavioral responses of 46 tinnitus subjects who underwent ten consecutive residual inhibition assessments were used for model fitting. Our model was able to replicate the behavioral responses during residual inhibition in our cohort (median linear correlation coefficient of 0.79). Using the same model, we simulated two additional tinnitus phenomena: residual excitation and occurrence of tinnitus in non-tinnitus subjects after sensory deprivation. In the simulations, the trajectories of the model were consistent with previously obtained behavioral and physiological observations. Our work introduces generative computational modeling to the research field of tinnitus. It has the potential to quantitatively link experimental observations to theoretical hypotheses and to support the search for neural signatures of tinnitus by finding correlates between the latent variables of the model and measured physiological data.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Hearing Research Laboratory

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Hu, Suyi; Zubler, Frédéric; Sznitman, Raphael; Anschütz, Lukas Peter; Caversaccio, Marco and Wimmer, Wilhelm

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0378-5955

Publisher:

Elsevier

Language:

English

Submitter:

Wilhelm Wimmer

Date Deposited:

15 Sep 2021 10:03

Last Modified:

19 Sep 2021 03:09

Publisher DOI:

10.1016/j.heares.2021.108338

PubMed ID:

34469780

BORIS DOI:

10.48350/158974

URI:

https://boris.unibe.ch/id/eprint/158974

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