CAR T-cell therapy and critical care : A survival guide for medical emergency teams.

Messmer, Anna S; Que, Yok-Ai; Schankin, Christoph; Banz, Yara; Bacher, Ulrike; Novak, Urban; Pabst, Thomas (2021). CAR T-cell therapy and critical care : A survival guide for medical emergency teams. Wiener klinische Wochenschrift, 133(23-24), pp. 1318-1325. Springer-Verlag 10.1007/s00508-021-01948-2

[img]
Preview
Text
Messmer2021_Article_CART-cellTherapyAndCriticalCar.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (409kB) | Preview

Chimeric antigen receptor (CAR) T‑cells are genetically engineered to give T‑cells the ability to attack specific cancer cells, and to improve outcome of patients with refractory/relapsed aggressive B‑cell malignancies. To date, several CAR T‑cell products are approved and additional products with similar indication or extended to other malignancies are currently being evaluated. Side effects of CAR T‑cell treatment are potentially severe or even life-threatening immune-related toxicities, specifically cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Consequently, medical emergency teams (MET) are increasingly involved in the assessment and management of CAR T‑cell recipients. This article describes the principles of CAR T‑cell therapy and summarizes the main complications and subsequent therapeutic interventions aiming to provide a survival guide for METs with a proposed management algorithm.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Messmer, Anna Sarah; Que, Yok-Ai; Schankin, Christoph Josef; Banz Wälti, Yara; Bacher, Vera Ulrike; Novak, Urban and Pabst, Thomas Niklaus

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0043-5325

Publisher:

Springer-Verlag

Language:

English

Submitter:

Pierrette Durand Lüthi

Date Deposited:

08 Nov 2021 16:08

Last Modified:

16 Dec 2021 00:13

Publisher DOI:

10.1007/s00508-021-01948-2

PubMed ID:

34613477

Uncontrolled Keywords:

Chimeric antigen receptor T‑cells Cytokine release syndrome Immune effector cell associated neurotoxicity Lymphoma Medical emergency team

BORIS DOI:

10.48350/160127

URI:

https://boris.unibe.ch/id/eprint/160127

Actions (login required)

Edit item Edit item
Provide Feedback