Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients.

Roten, Laurent; Goulouti, Eleni; Lam, Anna; Elchinova, Elena; Nozica, Nikolas; Spirito, Alessandro; Wittmer, Severin; Branca, Mattia; Servatius, Helge; Noti, Fabian; Seiler, Jens; Baldinger, Samuel H; Haeberlin, Andreas; De Marchi, Stefano; Asatryan, Babken; Rodondi, Nicolas; Donzé, Jacques; Aujesky, Drahomir; Tanner, Hildegard; Reichlin, Tobias; ... (2021). Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients. Journal of clinical medicine, 10(21), p. 4871. MDPI 10.3390/jcm10214871

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BACKGROUND

The prevalence of atrial fibrillation (AF) is high in older patients. The present study aimed to estimate the age and sex specific prevalence of clinical and screen-detected atrial fibrillation (AF) in hospitalized patients.

METHODS

The STAR-FIB cohort study was a prospective cohort study recruiting participants from a large source population of hospitalized patients aged 65-84 years. The estimated size of the source population was 26,035 (95% CI 25,918-26,152), and 795 consenting patients without clinical AF were included in the cohort study after stratification by sex and age (49.2% females; mean age 74.7 years). Patients in the cohort study underwent three seven-day Holter ECGs in intervals of two months to screen for AF.

RESULTS

In the source population, the estimated prevalence of clinical AF was 22.2% (95% CI 18.4-26.1), 23.8% for males (95% CI 20.9-26.6) and 19.8% for females (95% CI 17.3-22.4; p for difference between sexes, 0.004). There was a linear trend for an increase in the prevalence of clinical AF with increasing age, overall and in both sexes. In the cohort study, AF was newly diagnosed in 38 patients, for an estimated prevalence of screen-detected AF of 4.9% overall (95% CI 3.3-6.6), 5.5% in males (95% CI 3.2-7.8) and 4.0% in females (95% CI 2.0-6.0; p for difference between sexes, 0.041). The estimated prevalence of screen-detected AF in the source population was 3.8% overall, 4.2% in males and 3.2% in females.

CONCLUSION

In a large hospital-based patient population aged 65-84 years, the prevalence of clinical AF and of screen-detected AF was 22.2% and 3.8%, respectively, and significantly higher in males than females.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine

UniBE Contributor:

Roten, Laurent; Goulouti, Eleni; Lam, Anna; Elchinova, Elena Georgieva; Nozica, Nikolas; Spirito, Alessandro; Wittmer, Severin; Branca, Mattia; Servatius, Helge Simon; Noti, Fabian; Seiler, Jens; Baldinger, Samuel Hannes; Häberlin, Andreas David Heinrich; De Marchi, Stefano; Asatryan, Babken; Rodondi, Nicolas; Aujesky, Drahomir; Tanner, Hildegard and Reichlin, Tobias Roman

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2077-0383

Publisher:

MDPI

Funders:

[4] Swiss National Science Foundation ; [116] Swiss Heart Foundation = Schweizerische Herzstiftung

Language:

English

Submitter:

Babken Asatryan

Date Deposited:

16 Nov 2021 18:27

Last Modified:

16 Nov 2021 18:27

Publisher DOI:

10.3390/jcm10214871

PubMed ID:

34768391

Uncontrolled Keywords:

Holter ECG age atrial fibrillation cohort hospitalized paroxysmal prospective screening sex silent subclinical

BORIS DOI:

10.48350/160957

URI:

https://boris.unibe.ch/id/eprint/160957

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