Karolin, Andrea; Genitsch, Vera; Sidler, Daniel (2021). Calcineurin Inhibitor Toxicity in Solid Organ Transplantation. Pharmacology, 106(7-8), pp. 347-355. Karger 10.1159/000515933
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Calcineurin inhibitors (CNIs) have a substantial role in maintaining immunosuppression after solid organ transplantation (SOT). These drugs have a narrow therapeutic window, and individual doses and drug treatment monitoring are necessary. Still, a substantial proportion of patients suffer from short- or long-term calcineurin inhibitor toxicity (CNT), including kidney function impairment, hypertension, neuro- toxicity, and metabolic disturbances. The authors discuss pathophysiology, clinical presentation, and histological features of CNT, with focus on renal manifestations. Furthermore, we elucidate recent and ongoing attempts to reduce the burden of CNT in SOT including CNI-sparing and CNI-free regimens.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Karolin, Andrea Stephanie, Genitsch Gratwohl, Vera, Sidler, Daniel (A) |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0031-7012 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Andrea Stephanie Karolin |
Date Deposited: |
02 Dec 2021 13:40 |
Last Modified: |
29 Mar 2023 23:38 |
Publisher DOI: |
10.1159/000515933 |
PubMed ID: |
34130291 |
BORIS DOI: |
10.48350/161400 |
URI: |
https://boris.unibe.ch/id/eprint/161400 |
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