First European Haplotype of Echinococcus multilocularis Identified in the United States: An Emerging Disease?

Polish, Louis B; Pritt, Bobbi; Barth, Thomas F E; Gottstein, Bruno; O'Connell, Elise M; Gibson, Pamela C (2021). First European Haplotype of Echinococcus multilocularis Identified in the United States: An Emerging Disease? Clinical infectious diseases, 72(7), pp. 1117-1123. Oxford University Press 10.1093/cid/ciaa245

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BACKGROUND

Echinococcus multilocularis is one of the most severe and lethal parasitic diseases of humans, most often reported in Europe and Asia. Only 1 previous case has been documented in the contiguous United States from Minnesota in 1977. European haplotypes have been identified in carnivores and domestic dogs as well as recently in patients in western and central Canada.

METHODS

We used immunohistochemical testing with the monoclonal antibody Em2G11 and a species-specific enzyme-linked immunosorbent assay affinity-purified antigen Em2, as well as COX1 gene sequencing.

RESULTS

Using pathology, immunohistochemical staining, specific immunodiagnostic testing, and COX1 gene sequencing, we were able to definitively identify E. multilocularis as the causative agent of our patient's liver and lung lesions, which clustered most closely with the European haplotype.

CONCLUSIONS

We have identified the first case of a European haplotype E. multilocularis in the United States and the first case of this parasitic infection east of the Mississippi River. Given the identification of this haplotype in Canada, this appears to be an emerging infectious disease in North America.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Parasitology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Gottstein, Bruno

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1537-6591

Publisher:

Oxford University Press

Language:

English

Submitter:

Bruno Gottstein

Date Deposited:

26 Nov 2021 14:00

Last Modified:

05 Dec 2022 15:55

Publisher DOI:

10.1093/cid/ciaa245

PubMed ID:

32198510

Uncontrolled Keywords:

Echinococcus multilocularis Echinococcus multilocularis COX gene alveolar echinococcus spectrum of disease liver masses parasitic infection

BORIS DOI:

10.48350/161597

URI:

https://boris.unibe.ch/id/eprint/161597

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