Andronikou, Christina; Rottenberg, Sven (2021). Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance. Trends in molecular medicine, 27(7), pp. 630-642. Cell Press 10.1016/j.molmed.2021.04.010
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Histone eviction and chromatin relaxation are important processes for efficient DNA repair. Poly(ADP) ribose (PAR) polymerase 1 (PARP1) is a key mediator of this process, and disruption of PARP1 activity has a direct impact on chromatin structure. PARP inhibitors (PARPis) have been established as a treatment for BRCA1- or BRCA2-deficient tumors. Unfortunately, PARPi resistance occurs in many patients and the underlying mechanisms are not fully understood. In particular, it remains unclear how chromatin remodelers and histone chaperones compensate for the loss of the PARylation signal. In this Opinion article, we summarize currently known mechanisms of PARPi resistance. We discuss how the study of PARP1-mediated chromatin remodeling may help in further understanding PARPi resistance and finding new therapeutic approaches to overcome it.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Andronikou, Christina, Rottenberg, Sven |
Subjects: |
600 Technology > 630 Agriculture 500 Science > 570 Life sciences; biology |
ISSN: |
1471-499X |
Publisher: |
Cell Press |
Language: |
English |
Submitter: |
Christina Andronikou |
Date Deposited: |
01 Dec 2021 14:40 |
Last Modified: |
05 Dec 2022 15:55 |
Publisher DOI: |
10.1016/j.molmed.2021.04.010 |
PubMed ID: |
34030964 |
Uncontrolled Keywords: |
DNA damage response PARP inhibition chromatin remodeling drug resistance poly(ADP) ribosylation polymerase |
BORIS DOI: |
10.48350/161738 |
URI: |
https://boris.unibe.ch/id/eprint/161738 |
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