Benefit of Bovine Viral Diarrhoea (BVD) Eradication in Cattle on Pestivirus Seroprevalence in Sheep

Huser, Andrea Franziska; Schär, Jessica Grace; Bachofen, Claudia; de Martin, Elena; Portmann, Jasmine; Stalder, Hanspeter; Schweizer, Matthias (2021). Benefit of Bovine Viral Diarrhoea (BVD) Eradication in Cattle on Pestivirus Seroprevalence in Sheep. Frontiers in veterinary science, 8, p. 681559. Frontiers Media 10.3389/fvets.2021.681559

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Bovine viral diarrhoea virus (BVDV) and Border disease virus (BDV) are closely related pestiviruses of cattle and sheep, respectively. Both viruses may be transmitted between either species, but control programs are restricted to BVDV in cattle. In 2008, a program to eradicate bovine viral diarrhoea (BVD) in cattle was started in Switzerland. As vaccination is prohibited, the cattle population is now widely naïve to pestivirus infections. In a recent study, we determined that nearly 10% of cattle are positive for antibodies to BDV. Here, we show that despite this regular transmission of BDV from small ruminants to cattle, we could only identify 25 cattle that were persistently infected with BDV during the last 12 years of the eradication program. In addition, by determining the BVDV and BDV seroprevalence in sheep in Central Switzerland before and after the start of the eradication, we provide evidence that BVDV is transmitted from cattle to sheep, and that the BVDV seroprevalence in sheep significantly decreased after its eradication in cattle. While BDV remains endemic in sheep, the population thus profited at least partially from BVD eradication in cattle. Importantly, on a national level, BVD eradication does not appear to be generally derailed by the presence of pestiviruses in sheep. However, with every single virus-positive cow, it is necessary to consider small ruminants as a potential source of infection, resulting in costly but essential investigations in the final stages of the eradication program.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Huser, Andrea Franziska; Schär, Jessica Grace; Bachofen, Claudia; De Martin, Elena; Portmann, Jasmine; Stalder, Hanspeter and Schweizer, Matthias

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

2297-1769

Publisher:

Frontiers Media

Language:

English

Submitter:

Pamela Schumacher

Date Deposited:

28 Jan 2022 10:18

Last Modified:

05 Dec 2022 16:00

Publisher DOI:

10.3389/fvets.2021.681559

PubMed ID:

34671657

BORIS DOI:

10.48350/163631

URI:

https://boris.unibe.ch/id/eprint/163631

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