Current Limitations and Novel Perspectives in Pancreatic Cancer Treatment.

Robatel, Steve; Schenk, Mirjam (2022). Current Limitations and Novel Perspectives in Pancreatic Cancer Treatment. Cancers, 14(4) MDPI AG 10.3390/cancers14040985

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Pancreatic cancer is one of the deadliest cancers worldwide, largely due to its aggressive development. Consequently, treatment options are often palliative, as only one-fifth of patients present with potentially curable tumors. The only available treatment with curative intent is surgery followed by adjuvant chemotherapy. However, even for patients that are eligible for surgery, the 5-year OS remains below 10%. Hence, there is an urgent need to find new therapeutic regimens. In the first part of this review, we discuss the tumor staging method and its impact on the corresponding current standard-of-care treatments for PDAC. We also consider the key clinical trials over the last 20 years that have improved patient survival. In the second part, we provide an overview of the major components and cell types involved in PDAC, as well as their respective roles and interactions with each other. A deeper knowledge of the interactions taking place in the TME may lead to the discovery of potential new therapeutic targets. Finally, we discuss promising treatment strategies targeting specific components of the TME and potential combinations thereof. Overall, this review provides an overview of the current challenges and future perspectives in the treatment of pancreatic cancer.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Tumour Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Robatel, Steve Jacquy and Schenk, Mirjam

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2072-6694

Publisher:

MDPI AG

Language:

English

Submitter:

Pubmed Import

Date Deposited:

01 Mar 2022 15:14

Last Modified:

01 Mar 2022 15:22

Publisher DOI:

10.3390/cancers14040985

PubMed ID:

35205732

Uncontrolled Keywords:

PDAC TME cancer therapy pancreatic cancer

BORIS DOI:

10.48350/166103

URI:

https://boris.unibe.ch/id/eprint/166103

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