Differences in Atrial Remodeling in Hypertrophic Cardiomyopathy Compared to Hypertensive Heart Disease and Athletes’ Hearts.

Servatius, Helge; Raab, Simon; Asatryan, Babken; Haeberlin, Andreas; Branca, Mattia; De Marchi, Stefano; Brugger, Nicolas; Nozica, Nikolas; Goulouti, Eleni; Elchinova, Elena; Lam, Anna; Seiler, Jens; Noti, Fabian; Madaffari, Antonio; Tanner, Hildegard; Baldinger, Samuel H; Reichlin, Tobias; Wilhelm, Matthias; Roten, Laurent (2022). Differences in Atrial Remodeling in Hypertrophic Cardiomyopathy Compared to Hypertensive Heart Disease and Athletes’ Hearts. Journal of clinical medicine, 11(5), p. 1316. MDPI 10.3390/jcm11051316

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BACKGROUND:
Hypertrophic cardiomyopathy (HCM), hypertensive heart disease (HHD) and athletes' heart share an increased prevalence of atrial fibrillation. Atrial cardiomyopathy in these patients may have different characteristics and help to distinguish these conditions.

METHODS: In this single-center study, we prospectively collected and analyzed electrocardiographic (12-lead ECG, signal-averaged ECG (SAECG), 24 h Holter ECG) and echocardiographic data in patients with HCM and HHD and in endurance athletes. Patients with atrial fibrillation were excluded.

RESULTS: We compared data of 27 patients with HCM (70% males, mean age 50 +/- 14 years), 324 patients with HHD (52% males, mean age 75 +/- 5.5 years), and 215 endurance athletes (72% males, mean age 42 +/- 7.5 years). HCM patients had significantly longer filtered P-wave duration (153 +/- 26 ms) and PR interval (191 +/- 48 ms) compared to HHD patients (144 +/- 16 ms, p = 0.012 and 178 +/- 31, p = 0.034, respectively) and athletes (134 +/- 14 ms, p = 0.001 and 165 +/- 26 ms, both p &lt; 0.001, respectively). HCM patients had a mean of 4.9 +/- 16 premature atrial complexes per hour. Premature atrial complexes per hour were significantly more frequent in HHD patients (27 +/- 86, p &lt; 0.001), but not in athletes (2.7 +/- 23, p = 0.639). Left atrial volume index (LAVI) was 43 +/- 14 mL/m(2) in HCM patients and significantly larger than age- and sex-corrected LAVI in HHD patients 30 +/- 10 mL/m(2); p &lt; 0.001) and athletes (31 +/- 9.5 mL/m(2); p &lt; 0.001). A borderline interventricular septum thickness >/=13 mm and </=15 mm was found in 114 (35%) HHD patients, 12 (6%) athletes and 3 (11%) HCM patients.

CONCLUSIONS: Structural and electrical atrial remodeling is more advanced in HCM patients compared to HHD patients and athletes.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern

UniBE Contributor:

Servatius, Helge Simon; Asatryan, Babken; Häberlin, Andreas David Heinrich; Branca, Mattia; De Marchi, Stefano; Brugger, Nicolas Jacques; Nozica, Nikolas; Goulouti, Eleni; Elchinova, Elena Georgieva; Lam, Anna; Seiler, Jens; Noti, Fabian; Madaffari, Antonio; Tanner, Hildegard; Baldinger, Samuel Hannes; Reichlin, Tobias Roman; Wilhelm, Matthias and Roten, Laurent

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

2077-0383

Publisher:

MDPI

Funders:

[4] Swiss National Science Foundation ; [116] Swiss Heart Foundation = Schweizerische Herzstiftung

Language:

English

Submitter:

Helge Simon Servatius

Date Deposited:

09 Mar 2022 13:10

Last Modified:

21 Mar 2022 19:32

Publisher DOI:

10.3390/jcm11051316

PubMed ID:

35268407

BORIS DOI:

10.48350/166486

URI:

https://boris.unibe.ch/id/eprint/166486

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