Jegerlehner, Sabrina; Suter-Riniker, Franziska; Jent, Philipp; Bittel, Pascal; Nagler, Michael (2022). Diagnostic accuracy of SARS-CoV-2 saliva antigen testing in a real-life clinical setting. International journal of infectious diseases, 119, pp. 38-40. Elsevier 10.1016/j.ijid.2022.03.037
|
Text
1-s2.0-S120197122200176X-main.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (986kB) | Preview |
BACKGROUND
SARS-CoV-2 antigen tests with saliva facilitate examination in settings that lack trained personnel. However, little is known on the diagnostic accuracy in real-life clinical settings. Therefore, we studied the diagnostic accuracy of a saliva antigen test to diagnose SARS-CoV-2 infection in a primary/ secondary care testing facility.
METHODS
Individuals presented at a COVID-19 testing facility affiliated with a Swiss University Hospital were prospectively recruited (n=377). Saliva specimen was obtained, and the PCL Inc. COVID19 Gold antigen test was conducted in parallel with two real-time PCR.
RESULTS
RT-PCR was positive in 53 individuals, corresponding to a prevalence of 14.1% (missing material in one individual). The PCL saliva antigen test was positive in 22 individuals (5.8%), and negative in 354 (93.9%). The sensitivity of the saliva antigen test was 30.2% (95% confidence interval, CI, 18.3 to 44.3), both overall and in symptomatic individiduals. The specificity was 98.1% (96.0, 99.3).
CONCLUSIONS
The diagnostic accuracy of a SARS-CoV-2 saliva antigen test in a primary/ secondary care testing facility was remarkably lower compared to the manufacturers' specifications. Keywords Infections/*epidemiology/transmission; severe acute respiratory syndrome coronavirus 2 [Supplementary Concept]; COVID-19 diagnostic testing [Supplementary Concept] Background.
Actions (login required)
 |
Edit item |