Autophagy and Skin Diseases.

Klapan, Kim; Simon, Dagmar; Karaulov, Alexander; Gomzikova, Marina; Rizvanov, Albert; Yousefi, Shida; Simon, Hans-Uwe (2022). Autophagy and Skin Diseases. Frontiers in Pharmacology, 13, p. 844756. Frontiers 10.3389/fphar.2022.844756

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Autophagy is a highly conserved lysosomal degradation system that involves the creation of autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins and damaged organelles with their enzymes. Autophagy is widely known for its function in cellular homeostasis under physiological and pathological settings. Defects in autophagy have been implicated in the pathophysiology of a variety of human diseases. The new line of evidence suggests that autophagy is inextricably linked to skin disorders. This review summarizes the principles behind autophagy and highlights current findings of autophagy's role in skin disorders and strategies for therapeutic modulation.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Klapan, Kim; Simon, Dagmar; Yousefi, Shida and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1663-9812

Publisher:

Frontiers

Language:

English

Submitter:

Pubmed Import

Date Deposited:

05 Apr 2022 17:52

Last Modified:

10 Apr 2022 02:08

Publisher DOI:

10.3389/fphar.2022.844756

PubMed ID:

35370701

Uncontrolled Keywords:

atopic dermatitis autophagy inflammation psoriasis skin cancer

BORIS DOI:

10.48350/169012

URI:

https://boris.unibe.ch/id/eprint/169012

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