IL-33 biology in cancer: An update and future perspectives.

Yeoh, Wen Jie; Vu, Vivian P; Krebs, Philippe (2022). IL-33 biology in cancer: An update and future perspectives. Cytokine, 157, p. 155961. Elsevier 10.1016/j.cyto.2022.155961

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Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that is constitutively expressed in the nucleus of epithelial, endothelial and fibroblast-like cells. Upon cell stress, damage or necrosis, IL-33 is released into the cytoplasm to exert its prime role as an alarmin by binding to its specific receptor moiety, ST2. IL-33 exhibits pleiotropic function in inflammatory diseases and particularly in cancer. IL-33 may play a dual role as both a pro-tumorigenic and anti-tumorigenic cytokine, dependent on tumor and cellular context, expression levels, bioactivity and the nature of the inflammatory environment. In this review, we discuss the differential contribution of IL-33 to malignant or inflammatory conditions, its multifaceted effects on the tumor microenvironment, while providing possible explanations for the discrepant findings described in the literature. Additionally, we examine the emerging and divergent functions of IL-33 in the nucleus, and aspects of IL-33 biology that are currently under-addressed.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Yeoh, Wen Jie; Vu, Vivian Pham and Krebs, Philippe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1096-0023

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

20 Jul 2022 14:30

Last Modified:

10 Aug 2022 00:15

Publisher DOI:

10.1016/j.cyto.2022.155961

PubMed ID:

35843125

Uncontrolled Keywords:

Cancer Dual function IL-33 Immune cells Immuno regulation Inflammation ST2 Tumor microenvironment

BORIS DOI:

10.48350/171421

URI:

https://boris.unibe.ch/id/eprint/171421

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