Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance.

Pitton, Melissa; Oberhaensli, Simone; Appiah, Fiona; Pagani, Jean-Luc; Fournier, Anne; Jakob, Stephan M; Que, Yok-Ai; Cameron, David R (2022). Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance. Antimicrobial agents and chemotherapy, 66(7), e0062122. American Society for Microbiology 10.1128/aac.00621-22

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Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports of small-colony variant (SCV) emergence of P. aeruginosa, taken from a patient under aminoglycosides for a persistent burn wound infection. We confirm the causative role of a single ispA mutation in SCV emergence and increased aminoglycoside resistance. IspA is involved in the synthesis of ubiquinone, providing a possible link between electron transport and SCV formation in P. aeruginosa.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Intensivmedizin

Graduate School:

 Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

 Pitton, Melissa Phung-Kieu, Oberhänsli, Simone, Appiah, Fiona, Jakob, Stephan, Que, Yok-Ai, Cameron, David Robert

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 0066-4804

Publisher:

 American Society for Microbiology

Language:

 English

Submitter:

 Pubmed Import

Date Deposited:

 25 Jul 2022 14:01

Last Modified:

 05 Dec 2022 16:22

Publisher DOI:

 10.1128/aac.00621-22

PubMed ID:

 35852364

Uncontrolled Keywords:

 Pseudomonas aeruginosa SCV aminoglycosides antibiotic resistance burn wound infection gentamicin small-colony variant tobramycin

BORIS DOI:

 10.48350/171480

URI:

 https://boris.unibe.ch/id/eprint/171480

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