Brüggemann, Yannick; Kratzel, Annika; Almeida, Lea; Kelly, Jenna N; Thiel, Volker; Pfaender, Stephanie (2023). Conserved requirement of autophagy-related effectors during coronavirus replication. Autophagy, 19(2), pp. 731-733. Landes Bioscience 10.1080/15548627.2022.2100617
Full text not available from this repository.The recurrence of zoonotic transmission events highlights the need for novel treatment strategies against emerging coronaviruses (CoVs), namely SARS-CoV, MERS-CoV and most notably SARS-CoV-2. Our recently performed genome-wide CRISPR knockout screen revealed a list of conserved pan-coronavirus as well as MERS-CoV or HCoV-229E-specific host dependency factors (HDF) essential during the viral life cycle. Intriguingly, we identified the macroautophagy/autophagy pathway-regulating immunophilins FKBP8, TMEM41B, and MINAR1 as conserved MERS-CoV, HCoV-229E, SARS-CoV, and SARS-CoV-2 host factors, which further constitute potential targets for therapeutic intervention by clinically approved drugs.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Kratzel, Annika, Almeida, Lea, Kelly, Jenna Nicole, Thiel, Volker Earl |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
1554-8627 |
Publisher: |
Landes Bioscience |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
28 Jul 2022 09:16 |
Last Modified: |
18 Jan 2023 00:12 |
Publisher DOI: |
10.1080/15548627.2022.2100617 |
PubMed ID: |
35875965 |
Uncontrolled Keywords: |
Antiviral target CRISPR screen autophagy coronavirus host factor |
URI: |
https://boris.unibe.ch/id/eprint/171532 |
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