Collaborative challenges of multi-cohort project in pharmacogenetics - why time is essential for meaningful collaborations.

Franchini, Filippo; Kusejko, Katharina; Marzolini, Catia; Tellenbach, Christoph; Rossi, Simona; Stampf, Susanne; Koller, Michael; Stoyanov, Jivko; Möller, Burkhard; Leichtle, Alexander Benedikt (2022). Collaborative challenges of multi-cohort project in pharmacogenetics - why time is essential for meaningful collaborations. JMIR formative research, 6(9), e36759. JMIR Publications 10.2196/36759

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UNSTRUCTURED

Multi-cohort projects in medicine provide an opportunity to investigate scientific questions beyond the boundaries of a single institution, and to increase sample size for more reliable results. However, the complications of these kinds of collaborations arise during management, with many administrative hurdles. Hands-on approaches and lessons learned from previous collaborations provide solutions for optimized collaboration models. Here, we use our experience in running the Swiss multi-cohort project PGX-link to show the strategy we used to tackle different challenges from project set up to getting the relevant permits, including ethics approval. We set PGX-link into an international context, since our struggles were similar to those encountered during the SYNCHROS project. We provide ad-hoc solutions for cohorts, general project management strategies, and suggestions for unified protocols between cohorts that would ease current management hurdles. Project managers are not necessarily familiar with medical projects, and even if they are, they are not aware of the intricacies behind decision making, and consequently of the time needed to set up multi-cohort collaborations. This paper is meant to be a brief overview of what we went through with our multi-cohort project and provides the necessary practices for future managers.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Franchini, Filippo Luciano Charly; Stoyanov, Jivko; Möller, Burkhard and Leichtle, Alexander Benedikt

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2561-326X

Publisher:

JMIR Publications

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Pubmed Import

Date Deposited:

18 Aug 2022 10:12

Last Modified:

24 Oct 2022 18:00

Publisher DOI:

10.2196/36759

PubMed ID:

35976179

BORIS DOI:

10.48350/172152

URI:

https://boris.unibe.ch/id/eprint/172152

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