Collaborative challenges of multi-cohort project in pharmacogenetics - why time is essential for meaningful collaborations [viewpoint].

Franchini, Filippo; Kusejko, Katharina; Marzolini, Catia; Tellenbach, Christoph; Rossi, Simona; Stampf, Susanne; Koller, Michael; Stoyanov, Jivko; Möller, Burkhard; Leichtle, Alexander Benedikt (2022). Collaborative challenges of multi-cohort project in pharmacogenetics - why time is essential for meaningful collaborations [viewpoint]. JMIR formative research, 6(9), e36759. JMIR Publications 10.2196/36759

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Multi-cohort projects in medicine provide an opportunity to investigate scientific questions beyond the boundaries of a single institution, and to increase sample size for more reliable results. However, the complications of these kinds of collaborations arise during management, with many administrative hurdles. Hands-on approaches and lessons learned from previous collaborations provide solutions for optimized collaboration models. Here, we use our experience in running the Swiss multi-cohort project PGX-link to show the strategy we used to tackle different challenges from project set up to getting the relevant permits, including ethics approval. We set PGX-link into an international context, since our struggles were similar to those encountered during the SYNCHROS project. We provide ad-hoc solutions for cohorts, general project management strategies, and suggestions for unified protocols between cohorts that would ease current management hurdles. Project managers are not necessarily familiar with medical projects, and even if they are, they are not aware of the intricacies behind decision making, and consequently of the time needed to set up multi-cohort collaborations. This paper is meant to be a brief overview of what we went through with our multi-cohort project and provides the necessary practices for future managers.

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