Apoptosis in disease: about shortage and excess.

Brunner, Thomas; Mueller, Christoph (2003). Apoptosis in disease: about shortage and excess. Essays in biochemistry, 39, pp. 119-130. Portland Press 10.1042/bse0390119

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The death of cells by apoptosis is a fundamental event in development and the maintenance of cell homoeostasis. The other side of the coin, however, is that excessive cell death by apoptosis or the lack of apoptosis is often the driving force of many diseases. Whereas reduced apoptosis sensitivity is a basic characteristic of many tumour cells, accelerated tissue cell death and loss of tissue functions is the underlying cause of many auto-immune and inflammatory diseases.

Item Type:	Journal Article (Review Article)
Division/Institute:	04 Faculty of Medicine > Service Sector > Institute of Pathology
UniBE Contributor:	Brunner, Thomas (A), Müller, Christoph (C)
Subjects:	500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health
ISSN:	1744-1358
Publisher:	Portland Press
Language:	English
Submitter:	Christoph Müller
Date Deposited:	23 Sep 2022 10:47
Last Modified:	29 Mar 2023 23:38
Publisher DOI:	10.1042/bse0390119
PubMed ID:	14585078
URI:	https://boris.unibe.ch/id/eprint/173170