Brunner, Thomas (A)

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Sidler, D; Brockmann, A; Mueller, J; Nachbur, U; Corazza, N; Renzulli, P; Hemphill, A; Brunner, T (2012). Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase-Bim axis and reveals glutathione-S-transferase P1 as Achilles' heel. Oncogene, 31(37), pp. 4095-106. Basingstoke, UK: Nature Publishing Group 10.1038/onc.2011.575

Hostettler, N; Bianchi, P; Gennari-Moser, Carine; Kassahn, D; Schoonjans, K; Corazza, N; Brunner, T (2012). Local glucocorticoid production in the mouse lung is induced by immune cell stimulation. Allergy, 67(2), pp. 227-234. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2011.02749.x

Badmann, Anastasia; Langsch, Stephanie; Keogh, Adrian; Brunner, Thomas; Kaufmann, Thomas; Corazza, Nadia (2012). TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner. Cell death & disease, 3(12), e447. London: Nature Publishing Group 10.1038/cddis.2012.185


Badmann, A.; Keough, A.; Kaufmann, T.; Bouillet, P.; Brunner, T.; Corazza, N. (2011). Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage. Cell death & disease, 2(6), e171. London: Nature Publishing Group 10.1038/cddis.2011.55

Schmich, Kathrin; Schlatter, Rebekka; Corazza, Nadia; Sá Ferreira, Karine; Ederer, Michael; Brunner, Thomas; Borner, Christoph; Merfort, Irmgard (2011). Tumor necrosis factor sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner. Hepatology, 53(1), pp. 282-92. Hoboken, N.J.: Wiley Interscience 10.1002/hep.23987

Sidler, D; Renzulli, P; Schnoz, C; Berger, B; Schneider-Jakob, S; Flück, C; Inderbitzin, D; Corazza, N; Candinas, D; Brunner, T (2011). Colon cancer cells produce immunoregulatory glucocorticoids. Oncogene, 30(21), pp. 2411-9. Basingstoke, UK: Nature Publishing Group 10.1038/onc.2010.629


Noti, Mario; Corazza, Nadia; Tuffin, Gérald; Schoonjans, Kristina; Brunner, Thomas (2010). Lipopolysaccharide induces intestinal glucocorticoid synthesis in a TNFalpha-dependent manner. FASEB journal, 24(5), pp. 1340-6. Bethesda, Md.: Federation of American Societies for Experimental Biology 10.1096/fj.09-140913

Karamitopoulou, Eva; Zlobec, Inti; Tornillo, Luigi; Carafa, Vincenza; Schaffner, Thomas; Brunner, Thomas; Borner, Markus; Diamantis, Ioannis; Zimmermann, Arthur; Terracciano, Luigi (2010). Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN). Pathology, 42(3), pp. 229-34. London: Wolters Kluwer Lippincott Williams & Wilkins 10.3109/00313021003631379

Karamitopoulou, Eva; Pallante, Pierlorenzo; Zlobec, Inti; Tornillo, Luigi; Carafa, Vincenza; Schaffner, Thomas; Borner, Markus; Diamantis, Ioannis; Esposito, Francesco; Brunner, Thomas; Zimmermann, Arthur; Federico, Antonella; Terracciano, Luigi; Fusco, Alfredo (2010). Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. European journal of cancer, 46(8), pp. 1438-44. Amsterdam: Elsevier 10.1016/j.ejca.2010.01.033

Karamitopoulou, Eva; Rentsch, Cyrill A; Markwalder, Regula; Vallan, Claudio; Thalmann, George N; Brunner, Thomas (2010). Prognostic significance of apoptotic cell death in bladder cancer: a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens. Pathology, 42(1), pp. 37-42. London: Wolters Kluwer Lippincott Williams & Wilkins 10.3109/00313020903434397

Noti, Mario; Corazza, Nadia; Mueller, Christoph; Berger, Barbara; Brunner, Thomas (2010). TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis. Journal of experimental medicine, 207(5), pp. 1057-66. New York, N.Y.: Rockefeller University Press 10.1084/jem.20090849

Schneider-Jakob, S; Corazza, N; Badmann, A; Sidler, D; Stuber-Roos, R; Keogh, A; Frese, S; Tschan, M; Brunner, T (2010). Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid. Cell death & disease, 1(e86), e86. London: Nature Publishing Group 10.1038/cddis.2010.66


Luckschander, Nicole; Pfammatter, Nadia S; Sidler, Daniel; Jakob, Sabine; Burgener, Iwan A; Moore, Peter F; Zurbriggen, Andreas; Corazza, Nadia; Brunner, Thomas (2009). Phenotyping, functional characterization, and developmental changes in canine intestinal intraepithelial lymphocytes. Veterinary research, 40(6), p. 58. Paris: Editions scientifiques Elsevier 10.1051/vetres/2009042

Corazza, Nadia; Kassahn, Daniela; Jakob, Sabine; Badmann, Anastasia; Brunner, Thomas (2009). TRAIL-induced apoptosis: between tumor therapy and immunopathology. Annals of the New York Academy of Sciences, 1171, pp. 50-58. Boston, Mass.: Blackwell 10.1111/j.1749-6632.2009.04905.x

Müller, Stefan; Rihs, Silvia; Dayer Schneider, Johanna M; Paredes, Bruno E; Seibold, Ingeborg; Brunner, Thomas; Mueller, Christoph (2009). Soluble TNF-alpha but not transmembrane TNF-alpha sensitizes T cells for enhanced activation-induced cell death. European journal of immunology, 39(11), pp. 3171-80. Weinheim: Wiley-VCH 10.1002/eji.200939554

Bandi, Nora; Zbinden, Samuel; Gugger, Mathias; Arnold, Marlene; Kocher, Verena; Hasan, Lara; Kappeler, Andreas; Brunner, Thomas; Vassella, Erik (2009). miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. Cancer research, 69(13), pp. 5553-9. Birmingham, Ala.: American Association for Cancer Research AACR 10.1158/0008-5472.CAN-08-4277

Noti, Mario; Sidler, Daniel; Brunner, Thomas (2009). Extra-adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean? Seminars in immunopathology, 31(2), pp. 237-48. Berlin: Springer-Verlag 10.1007/s00281-009-0159-2

Brunner, Thomas (2009). Living on the edge: immune cells and immunopathology in the intestinal mucosa. Seminars in immunopathology, 31(2), pp. 143-4. Berlin: Springer-Verlag 10.1007/s00281-009-0162-7

Kassahn, D; Nachbur, U; Conus, S; Micheau, O; Schneider, P; Simon, H-U; Brunner, T (2009). Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells. Cell death and differentiation, 16(1), pp. 115-24. Basingstoke: Nature Publishing Group 10.1038/cdd.2008.133


Karamitopoulou, Eva; Tornillo, Luigi; Zlobec, Inti; Cioccari, Lukas; Carafa, Vincenza; Borner, Markus; Schaffner, Thomas; Brunner, Thomas; Diamantis, Ioannis; Zimmermann, Arthur; Terracciano, Luigi (2008). Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas. American journal of clinical pathology, 130(5), pp. 780-6. Chicago, Ill.: American Society for Clinical Pathology 10.1309/AJCP35FDCAVANWMM

Jakob, Sabine; Corazza, Nadia; Diamantis, Eva; Kappeler, Andreas; Brunner, Thomas (2008). Detection of apoptosis in vivo using antibodies against caspase-induced neo-epitopes. Methods, 44(3), pp. 255-61. San Diego, Calif.: Elsevier 10.1016/j.ymeth.2007.11.004

Brumatti, G; Yon, M; Castro, F A; Bueno-da-Silva, A E B; Jacysyn, J F; Brunner, T; Amarante-Mendes, G P (2008). Conversion of CD95 (Fas) Type II into Type I signaling by sub-lethal doses of cycloheximide. Experimental cell research, 314(3), pp. 554-63. San Diego, Calif.: Elsevier 10.1016/j.yexcr.2007.11.003

Herold, Susanne; Steinmueller, Mirko; von Wulffen, Werner; Cakarova, Lidija; Pinto, Ruth; Pleschka, Stephan; Mack, Matthias; Kuziel, William A; Corazza, Nadia; Brunner, Thomas; Seeger, Werner; Lohmeyer, Juergen (2008). Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand. Journal of experimental medicine, 205(13), pp. 3065-77. New York, N.Y.: Rockefeller University Press 10.1084/jem.20080201

Kassahn, Daniela; Brunner, Thomas; Corazza, Nadia (2008). Distinct but complementary roles of Fas ligand and Bim in homeostatic T cell apoptosis. Cell cycle, 7(21), pp. 3469-71. Georgetown, Tex.: Landes Bioscience 10.4161/cc.7.21.6929

Didichenko, Svetlana A; Spiegl, Nicole; Brunner, Thomas; Dahinden, Clemens A (2008). IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils. Blood, 112(10), pp. 3949-58. Washington, D.C.: American Society of Hematology 10.1182/blood-2008-04-149419

Atanasov, Atanas G; Leiser, Dominic; Roesselet, Corinne; Noti, Mario; Corazza, Nadia; Schoonjans, Kristina; Brunner, Thomas (2008). Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells. FASEB journal, 22(12), pp. 4117-25. Bethesda, Md.: Federation of American Societies for Experimental Biology 10.1096/fj.08-114157

Müller, Joachim; Sidler, Daniel; Nachbur, Ueli; Wastling, Jonathan; Brunner, Thomas; Hemphill, Andrew (2008). Thiazolides inhibit growth and induce glutathione-S-transferase Pi (GSTP1)-dependent cell death in human colon cancer cells. International journal of cancer, 123(8), pp. 1797-806. Malden, Mass.: Wiley-Blackwell 10.1002/ijc.23755


Mueller, Matthias; Atanasov, Atanas; Cima, Igor; Corazza, Nadia; Schoonjans, Kristina; Brunner, Thomas (2007). Differential regulation of glucocorticoid synthesis in murine intestinal epithelial versus adrenocortical cell lines. Endocrinology, 148(3), pp. 1445-53. Chevy Chase, Md.: Endocrine Society 10.1210/en.2006-0591

Kassahn, D; Nachbur, U; Brunner, T (2007). CD95L pro-drug: a novel Swiss Army Knife in cancer therapy? Cell death and differentiation, 14(3), pp. 393-4. Basingstoke: Nature Publishing Group 10.1038/sj.cdd.4402069

Karamitopoulou, Eva; Cioccari, Luca; Jakob, Sabine; Vallan, Claudio; Schaffner, Thomas; Zimmermann, Arthur; Brunner, Thomas (2007). Active caspase 3 and DNA fragmentation as markers for apoptotic cell death in primary and metastatic liver tumours. Pathology, 39(6), pp. 558-64. London: Wolters Kluwer Lippincott Williams & Wilkins 10.1080/00313020701684375

Coste, Agnes; Dubuquoy, Laurent; Barnouin, Romain; Annicotte, Jean-Sebastien; Magnier, Benjamin; Noti, Mario; Corazza, Nadia; Antal, Maria Cristina; Metzger, Daniel; Desreumaux, Pierre; Brunner, Thomas; Auwerx, Johan; Schoonjans, Kristina (2007). LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 104(32), pp. 13098-13103. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.0702440104

Plock, Jan; Frese, Steffen; Keogh, Adrian; Bisch-Knaden, Sonja; Ayuni, Erick; Corazza, Nadia; Weikert, Christian; Jakob, Stephan; Erni, Dominique; Dufour, Jean-François; Brunner, Thomas; Candinas, Daniel; Stroka, Deborah (2007). Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liver. Journal of hepatology, 47(4), pp. 538-45. Amsterdam: Elsevier 10.1016/j.jhep.2007.04.016


Yousefi, Shida; Perozzo, Remo; Schmid, Inès; Ziemiecki, Andrew; Schaffner, Thomas; Scapozza, Leonardo; Brunner, Thomas; Simon, Hans-Uwe (2006). Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nature cell biology, 8(10), pp. 1124-32. London: Nature Publishing Group 10.1038/ncb1482

Nachbur, Ueli; Kassahn, Daniela; Yousefi, Shida; Legler, Daniel F; Brunner, Thomas (2006). Posttranscriptional regulation of Fas (CD95) ligand killing activity by lipid rafts. Blood, 107(7), pp. 2790-6. Washington, D.C.: American Society of Hematology 10.1182/blood-2005-07-2744

Mueller, Matthias; Cima, Igor; Noti, Mario; Fuhrer, Andrea; Jakob, Sabine; Dubuquoy, Laurent; Schoonjans, Kristina; Brunner, Thomas (2006). The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine. Journal of experimental medicine, 203(9), pp. 2057-62. New York, N.Y.: Rockefeller University Press 10.1084/jem.20060357

Cima, Igor; Fuhrer, Andrea; Brunner, Thomas (2006). Antagonistic and synergistic effects of glucocorticoids and IL-7 on CD4+ T cell activation. Immunology letters, 106(1), pp. 99-102. Amsterdam: Elsevier 10.1016/j.imlet.2006.04.005

Matter, Christian M; Chadjichristos, Christos E; Meier, Patricia; von Lukowicz, Tobias; Lohmann, Christine; Schuler, Pia K; Zhang, Dongming; Odermatt, Bernhard; Hofmann, Eugen; Brunner, Thomas; Kwak, Brenda R; Lüscher, Thomas F (2006). Role of endogenous Fas (CD95/Apo-1) ligand in balloon-induced apoptosis, inflammation, and neointima formation. Circulation, 113(15), pp. 1879-87. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/CIRCULATIONAHA.106.611731

Corazza, Nadia; Jakob, Sabine; Schaer, Corinne; Frese, Steffen; Keogh, Adrian; Stroka, Deborah; Kassahn, Daniela; Torgler, Ralph; Mueller, Christoph; Schneider, Pascal; Brunner, Thomas (2006). TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality. Journal of clinical investigation, 116(9), pp. 2493-9. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI27726

Keogh-Stroka, Deborah M.; Plock, Jan Alexander; Beldi, Guido; Frese, Steffen R.; Keogh, Adrian; Bisch-Knaden, Sonja Maria; Dufour, Jean-François; Brunner, Thomas; Candinas, Daniel (2006). Temporary hypoxic stress protects the liver from Fas-mediated apoptosis and ischemia reperfusion injury. In: 93. Jahreskongress der Schweizerischen Gesellschaft für Chirurgie. Lugano, Switzerland. 21.-23.6.2006.


Cima, Igor; Corazza, Nadia; Dick, Bernhard; Fuhrer, Andrea; Herren, Simon; Jakob, Sabine; Ayuni, Erick; Mueller, Christoph; Brunner, Thomas (2004). Intestinal epithelial cells synthesize glucocorticoids and regulate T cell activation. Journal of experimental medicine, 200(12), pp. 1635-1646. Rockefeller University Press 10.1084/jem.20031958

Wiener, Zoltan; Ontsouka, Edgar C; Jakob, Sabine; Torgler, Ralph; Falus, Andras; Mueller, Christoph; Brunner, Thomas (2004). Synergistic induction of the Fas (CD95) ligand promoter by Max and NFkappaB in human non-small lung cancer cells. Experimental cell research, 299(1), pp. 227-235. Elsevier 10.1016/j.yexcr.2004.05.031

Torgler, Ralph; Jakob, Sabine; Ontsouka, Edgar; Nachbur, Ulrich; Mueller, Christoph; Green, Douglas R; Brunner, Thomas (2004). Regulation of activation-induced Fas (CD95/Apo-1) ligand expression in T cells by the cyclin B1/Cdk1 complex. Journal of biological chemistry, 279(36), pp. 37334-37342. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M406913200


Wasem, Christoph; Arnold, Diana; Saurer, Leslie; Corazza, Nadia; Jakob, Sabine; Herren, Simon; Vallan, Claudio; Mueller, Christoph; Brunner, Thomas (2003). Sensitizing antigen-specific CD8+ T cells for accelerated suicide causes immune incompetence. Journal of clinical investigation, 111(8), pp. 1191-1199. American Society for Clinical Investigation 10.1172/JCI16344

Brunner, Thomas; Mueller, Christoph (2003). Apoptosis in disease: about shortage and excess. Essays in biochemistry, 39, pp. 119-130. Portland Press 10.1042/bse0390119


Arnold, Diana; Wasem, Christoph; Juillard, Pierre; Graber, Pierre; Cima, Igor; Frutschi, Corina; Herren, Simon; Schneider, Sabine; Alouani, Sami; Mueller, Christoph; Chvatchko, Yolande; Brunner, Thomas (2002). IL‐18‐independent cytotoxic T lymphocyte activation and IFN‐γ production during experimental acute graft‐versus‐host disease. International immunology, 14(5), pp. 503-511. Oxford University Press 10.1093/intimm/14.5.503


Wasem, Christoph; Frutschi, Corina; Arnold, Diana; Vallan, Claudio; Lin, Tesu; Green, Douglas R; Mueller, Christoph; Brunner, Thomas (2001). Accumulation and activation-induced release of preformed Fas (CD95) ligand during the pathogenesis of experimental graft-versus-host disease. The journal of immunology, 167(5), pp. 2936-2941. American Association of Immunologists 10.4049/jimmunol.167.5.2936


Corazza, Nadia; Müller, Stefan; Brunner, Thomas; Kägi, David; Mueller, Christoph (2000). Differential contribution of Fas- and perforin-mediated mechanisms to the cell-mediated cytotoxic activity of naive and in vivo-primed intestinal intraepithelial lymphocytes. The journal of immunology, 164(1), pp. 398-403. American Association of Immunologists 10.4049/jimmunol.164.1.398


Müller, Christoph; Corazza, Nadia; Trachsel-Løseth, Sissel; Eugster, Hans-Pietro; Bühler-Jungo, Myriam; Brunner, Thomas; Imboden, Martin A (1999). Noncleavable transmembrane mouse tumor necrosis factor-alpha (TNFalpha) mediates effects distinct from those of wild-type TNFalpha in vitro and in vivo. The journal of biological chemistry, 274(53), pp. 38112-38118. American Society for Biochemistry and Molecular Biology 10.1074/jbc.274.53.38112

Brunner, Thomas; Arnold, Diana; Wasem, Christoph; Laissue, Jean A; Mueller, Christoph (1999). Death receptor-mediated suicide: a novel target of autoimmune disease treatment. Expert opinion on investigational drugs, 8(9), pp. 1359-1372. Taylor & Francis 10.1517/13543784.8.9.1359

Brunner, Thomas; Mueller, Christoph (1999). Is autoimmunity coming to a Fas(t) end? Nature medicine, 5(1), pp. 19-20. Nature Publishing Group 10.1038/4695

Brunner, Thomas; Mueller, Christoph (1999). Cytotoxic T cells: Double-barreled shot guns. Nature medicine, 5(1), p. 20. Nature Publishing Group 10.1038/4697

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