Mitochondrial genome maintenance - the kinetoplast story.

Amodeo, Simona; Bregy, Irina; Ochsenreiter, Torsten (2023). Mitochondrial genome maintenance - the kinetoplast story. FEMS microbiology reviews, 47(6) Blackwell Publishing Ltd 10.1093/femsre/fuac047

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Mitochondrial DNA replication is an essential process in most eukaryotes. Similar to the diversity in mitochondrial genome size and organization in the different eukaryotic supergroups, there is considerable diversity in the replication process of the mitochondrial DNA. In this review, we summarize the current knowledge of mitochondrial DNA replication and the associated factors in trypanosomes with a focus on Trypanosoma brucei, and provide a new model of minicircle replication for this protozoan parasite. The model assumes the mitochondrial DNA (kinetoplast DNA, kDNA) of T. brucei to be loosely diploid in nature and the replication of the genome to occur at two replication centers at the opposing ends of the kDNA disc (also known as antipodal sites, APS). The new model is consistent with the localization of most replication factors and in contrast to the current model, it does not require the assumption of an unknown sorting and transport complex moving freshly replicated DNA to the antipodal sites. In combination with the previously proposed sexual stages of the parasite in the insect vector, the new model provides a mechanism for maintenance of the mitochondrial genetic diversity.

Item Type:

Journal Article (Original Article)

Division/Institute:

09 Interdisciplinary Units > Microscopy Imaging Center (MIC)
08 Faculty of Science > Department of Biology > Institute of Cell Biology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Amodeo, Simona, Bregy, Irina, Ochsenreiter, Torsten

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0168-6445

Publisher:

Blackwell Publishing Ltd

Language:

English

Submitter:

Pubmed Import

Date Deposited:

01 Dec 2022 08:46

Last Modified:

19 Sep 2024 14:56

Publisher DOI:

10.1093/femsre/fuac047

PubMed ID:

36449697

Uncontrolled Keywords:

Kinetoplast Trypanosomes kDNA mitochondrial DNA mitochondrial DNA replication

BORIS DOI:

10.48350/175368

URI:

https://boris.unibe.ch/id/eprint/175368

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