Niederhauser, Christoph; Tinguely, Caroline; Stolz, Martin; Vock, Michael; Amar El Dusouqui, Soraya; Gowland, Peter (2022). Evolution of Blood Safety in Switzerland over the Last 25 years for HIV, HCV, HBV and Treponema pallidum. Viruses, 14(12), pp. 1-17. MDPI 10.3390/v14122611
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Abstract: During the last few decades, efforts to increase the safety of blood and blood products
have mainly focused on preventing the viral infections HCV, HIV, HBV and Treponema pallidum. The
evolution of these approaches and the achieved increase in safety is shown for the last 25 years in
Switzerland. In detail, the prevalences and incidences of the infection disease and the theoretical
estimated residual risks (RR) of these blood-borne infections are presented. Prevalences, incidences
and, in particular, the RR have decreased considerably over the last 25 years. This was achieved
primarily by the adoption of strict criteria for the selection of blood donors, refined questionnaires, the
introduction of increasingly sensitive serological screening tests and the implementation of nucleic
acid testing (NAT) for these blood-borne pathogens. These NAT assays have significantly shortened
the window period between infection and the first detection of the infectious agent in the blood of
an infected individual. A form of “real life” comparison or confirmation is provided by the reported
lookback procedures (LBP) and the haemovigilance data of the Swiss competent authority, Swissmedic.
These data are in agreement, and thus support the very low prevalences, incidences and RR.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Mathematics and Statistics > Institute of Mathematical Statistics and Actuarial Science 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Niederhauser-Lüthi, Christoph Peter, Vock, Michael |
Subjects: |
300 Social sciences, sociology & anthropology > 360 Social problems & social services 500 Science > 510 Mathematics 600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
1999-4915 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Christoph Peter Niederhauser-Lüthi |
Date Deposited: |
09 Dec 2022 11:39 |
Last Modified: |
07 Aug 2024 15:45 |
Publisher DOI: |
10.3390/v14122611 |
BORIS DOI: |
10.48350/175641 |
URI: |
https://boris.unibe.ch/id/eprint/175641 |
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