Alzheimer's Disease: A Brief History of Immunotherapies Targeting Amyloid β.

Vogt, Anne-Cathrine S; Jennings, Gary T; Mohsen, Mona O; Vogel, Monique; Bachmann, Martin F (2023). Alzheimer's Disease: A Brief History of Immunotherapies Targeting Amyloid β. International journal of molecular sciences, 24(4) MDPI 10.3390/ijms24043895

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Alzheimer's disease (AD) is the most common form of dementia and may contribute to 60-70% of cases. Worldwide, around 50 million people suffer from dementia and the prediction is that the number will more than triple by 2050, as the population ages. Extracellular protein aggregation and plaque deposition as well as accumulation of intracellular neurofibrillary tangles, all leading to neurodegeneration, are the hallmarks of brains with Alzheimer's disease. Therapeutic strategies including active and passive immunizations have been widely explored in the last two decades. Several compounds have shown promising results in many AD animal models. To date, only symptomatic treatments are available and because of the alarming epidemiological data, novel therapeutic strategies to prevent, mitigate, or delay the onset of AD are required. In this mini-review, we focus on our understanding of AD pathobiology and discuss current active and passive immunomodulating therapies targeting amyloid-β protein.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute for Immunology [discontinued]
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Vogt, Anne-Cathrine Sarah, Mohsen, Mona Omar Mahmoud, Vogel, Monique, Bachmann, Martin (B)

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1422-0067

Publisher:

MDPI

Language:

English

Submitter:

Pubmed Import

Date Deposited:

03 Mar 2023 16:37

Last Modified:

29 Mar 2023 23:38

Publisher DOI:

10.3390/ijms24043895

PubMed ID:

36835301

Uncontrolled Keywords:

Alzheimer’s disease amyloid-β immunotherapy

BORIS DOI:

10.48350/179249

URI:

https://boris.unibe.ch/id/eprint/179249

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