Disrupted longitudinal restoration of brain connectivity during weight normalization in severe anorexia nervosa.

Kaufmann, Lisa-Katrin; Hänggi, Jürgen; Jäncke, Lutz; Baur, Volker; Piccirelli, Marco; Kollias, Spyros; Schnyder, Ulrich; Martin-Soelch, Chantal; Milos, Gabriella (2023). Disrupted longitudinal restoration of brain connectivity during weight normalization in severe anorexia nervosa. Translational Psychiatry, 13(1), p. 136. Springer Nature 10.1038/s41398-023-02428-z

Preview

Text s41398-023-02428-z.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (2MB) | Preview

Altered intrinsic brain connectivity of patients with anorexia nervosa has been observed in the acute phase of the disorder, but it remains unclear to what extent these alterations recover during weight normalization. In this study, we used functional imaging data from three time points to probe longitudinal changes in intrinsic connectivity patterns in patients with severe anorexia nervosa (BMI ≤ 15.5 kg/m2) over the course of weight normalization. At three distinct stages of inpatient treatment, we examined resting-state functional connectivity in 27 women with severe anorexia nervosa and 40 closely matched healthy controls. Using network-based statistics and graph-theoretic measures, we examined differences in global network strength, subnetworks with altered intrinsic connectivity, and global network topology. Patients with severe anorexia nervosa showed weakened intrinsic connectivity and altered network topology which did not recover during treatment. The persistent disruption of brain networks suggests sustained alterations of information processing in weight-recovered severe anorexia nervosa.

Interest & Impact

Downloads

15 since deposited on 01 May 2023
11 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item