Brown, Jennifer A; Hauser, Anthony; Abela, Irene A; Pasin, Chloé; Epp, Selina; Mohloanyane, Tsepang; Nsakala, Bienvenu L; Trkola, Alexandra; Labhardt, Niklaus D; Kouyos, Roger D; Günthard, Huldrych F (2023). Seroprofiling of antibodies against endemic human coronaviruses and SARS-CoV-2 in an HIV cohort in Lesotho: correlates of antibody response and seropositivity. Journal of infectious diseases, 228(8), pp. 1042-1054. Oxford University Press 10.1093/infdis/jiad197
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BACKGROUND
Serological data on endemic human coronaviruses (HCoVs) and SARS-CoV-2 in southern Africa are scarce. Here, we report on i) endemic HCoV seasonality, ii) SARS-CoV-2 seroprevalence, and iii) predictive factors for SARS-CoV-2 seropositivity and strength of SARS-CoV-2 and HCoV serological response during a 17-month period at the start of the COVID-19 pandemic among adults living with HIV.
METHODS
Plasma samples were collected from February 2020 to July 2021 within an outpatient HIV cohort in Lesotho. We used the ABCORA multiplex immunoassay to measure antibody responses to endemic HCoV (OC43, HKU1, NL63, and 229E) and SARS-CoV-2 antigens.
RESULTS
Results of 3'173 samples from 1'403 adults were included. Serological responses against endemic HCoVs increased over time and peaked in winter/spring. SARS-CoV-2 seropositivity reached >35% among samples collected in early 2021 and was associated with female sex (p = 0.004), obesity (p < 0.001), working outside the home (p = 0.02), and recent tiredness (p = 0.005) or fever (p = 0.007). Positive correlations were observed between the strength of response to endemic HCoVs and to SARS-CoV-2, and between older age or obesity and the IgG response to SARS-CoV-2.
CONCLUSIONS
These results add to our understanding of the impact of biological, clinical, and social/behavioural factors on serological responses to coronaviruses in southern Africa.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Hauser, Anthony Willy |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0022-1899 |
Publisher: |
Oxford University Press |
Funders: |
[4] Swiss National Science Foundation |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
05 Jun 2023 15:04 |
Last Modified: |
20 Oct 2023 16:21 |
Publisher DOI: |
10.1093/infdis/jiad197 |
PubMed ID: |
37261930 |
Additional Information: |
J. A. B., A. H., and I. A. A. contributed equally to this work. |
Uncontrolled Keywords: |
COVID-19 HIV Serology coronavirus immunoassay seroepidemiologic studies southern Africa |
BORIS DOI: |
10.48350/183123 |
URI: |
https://boris.unibe.ch/id/eprint/183123 |
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